与其他类型的癌症相比，头颈癌患者的口腔健康状况较差。
Head and neck cancer patients show poor oral health as compared to those with other types of cancer.
发表日期：2023 Sep 06
作者：
Hiromi Nishi, Taiji Obayashi, Tsutomu Ueda, Kouji Ohta, Hideo Shigeishi, Syuichi Munenaga, Takashi Kono, Yukio Yoshioka, Masaru Konishi, Ryotaro Taga, Yuya Toigawa, Takako Naruse, Eri Ishida, Eri Tsuboi, Kanae Oda, Kana Dainobu, Tomoko Tokikazu, Kotaro Tanimoto, Naoya Kakimoto, Hiroki Ohge, Hidemi Kurihara, Hiroyuki Kawaguchi
来源：
BMC Oral Health
摘要：
一些研究已经发现了牙周炎与各种类型癌症之间的关联。由于头颈部癌症（HNC）的发生部位与口腔相邻或接近，因此其可能受到口腔炎症的影响尤为明显。本研究旨在确定HNC患者的口腔健康状况是否相对于其他类型癌症患者较差。本研究以回顾性为基础，对包括牙周炎炎症表面积（PISA）在内的口腔环境因素进行了研究，这是一种新的牙周炎炎症参数。总共研究了1030名癌症患者，分为HNC组（n = 142）和其他癌症组（n = 888）。此外，HNC组又根据PISA值分为高PISA（n = 71）和低PISA（n = 71）两个亚组，并对可能影响高PISA值的独立危险因素进行了调查。多元逻辑回归分析结果显示，缺失牙齿数量（比值比1.72，95% CI 1.15-2.56，P < 0.01）、PISA值（比值比1.06，95% CI 1.03-1.06，P < 0.05）和口腔细菌计数（比值比1.02，95% CI 1.01-1.03，P < 0.01）是与HNC相关的独立因素。此外，多元逻辑回归分析还表明，目前吸烟者（比值比7.51，95% CI 1.63-34.71，P < 0.01）和未治疗的牙齿龋齿（比值比3.33，95% CI 1.23-9.00，P < 0.05）是影响HNC患者高PISA值的独立危险因素。HNC患者存在更高水平的牙龈炎症和较差的口腔健康状况，这表明在HNC诊断时需要及时进行口腔评估并制定有效的口腔卫生管理计划。© 2023. BioMed Central Ltd., part of Springer Nature.
Several studies have found associations between periodontitis and various types of cancer. Since the site of head and neck cancer (HNC) has contiguity or proximity to the oral cavity, it may be particularly influenced by oral inflammation. This study aimed to determine whether HNC patients have poor oral health as compared to those with other types of cancer.This study retrospectively examined oral environmental factors including periodontal inflamed surface area (PISA), a new periodontal inflammatory parameter. A total of 1030 cancer patients were divided into the HNC (n = 142) and other cancer (n = 888) groups. Furthermore, the HNC group was divided into high (n = 71) and low (n = 71) PISA subgroups, and independent risk factors affecting a high PISA value were investigated.Multivariate logistic regression analysis showed that number of missing teeth (odds ratio 1.72, 95% CI 1.15-2.56, P < 0.01), PISA (odds ratio 1.06, 95% CI 1.03-1.06, P < 0.05), and oral bacterial count (odds ratio 1.02, 95% CI 1.01-1.03, P < 0.01) were independent factors related to HNC. In addition, multivariate logistic regression analysis indicated that current smoker (odds ratio 7.51, 95% CI 1.63-34.71, P < 0.01) and presence of untreated dental caries (odds ratio 3.33, 95% CI 1.23-9.00, P < 0.05) were independent risk factors affecting high PISA values in HNC patients.HNC patients have higher levels of gingival inflammation and poor oral health as compared to patients with other types of cancer, indicating that prompt oral assessment and an effective oral hygiene management plan are needed at the time of HNC diagnosis.© 2023. BioMed Central Ltd., part of Springer Nature.