癌症中受p53调控的长链非编码RNA：从增殖和转移到治疗。
p53-regulated lncRNAs in cancers: from proliferation and metastasis to therapy.
发表日期：2023 Sep 07
作者：
Kaixin Yang, Yinan Xiao, Linghui Zhong, Wenyang Zhang, Peng Wang, Yaru Ren, Lei Shi
来源：
CANCER GENE THERAPY
摘要：
长链非编码RNA（lncRNA）已被确认为通过转录、翻译、蛋白修饰和RNA-蛋白复合物等多种机制来调控基因的主要调节因子。lncRNA的失调经常与各种生物功能和人类疾病（包括癌症）相关。p53网络是一个关键的肿瘤抑制机制，通过转录激活靶基因来抑制人类恶性肿瘤的细胞增殖。最近的研究表明，lncRNA在p53信号通路中起着重要的作用。在这篇综述中，我们总结了关于lncRNA在p53相关功能中的当前认识，并概述了这些异常的lncRNA如何促进肿瘤的发生和发展。我们还讨论了lncRNA与p53上下游基因的关联。这些发现表明，lncRNA可以帮助鉴定可能成为癌症治疗的有前途的潜在生物标志物和治疗靶点的细胞易感性。© 2023. 来自于 Springer Nature America, Inc. 的独家许可授权给作者。
Long non-coding RNAs (lncRNAs) have been identified as master gene regulators through various mechanisms such as transcription, translation, protein modification and RNA-protein complexes. LncRNA dysregulation is frequently associated with a variety of biological functions and human diseases including cancer. The p53 network is a key tumor-suppressive mechanism that transcriptionally activates target genes to suppress cellular proliferation in human malignancies. Recent research indicates that lncRNAs play an important role in the p53 signaling pathway. In this review, we summarize the current knowledge of lncRNAs in p53-relevant functions and provide an overview of how these altered lncRNAs contribute to tumor initiation and progression. We also discuss the association between lncRNA and up- or downstream genes of p53. These findings imply that lncRNAs can help identify cellular vulnerabilities that may prove to be promising potential biomarkers and therapeutic targets for cancer treatment.© 2023. The Author(s), under exclusive licence to Springer Nature America, Inc.