近几十年来，结直肠癌的存活率有所提高，但人们担心幸存者可能由于癌症治疗的不良影响或癌症本身的并发症而发生肾脏问题。我们对结直肠癌幸存者与没有先前癌症的人进行了急性肾损伤（AKI）风险的量化比较。采用回顾性配对队列研究，利用与英国（HES-APC）医院数据相连的临床实践研究数据链黄金的电子健康记录初级护理数据。将1997年至2018年间的结直肠癌患者与年龄、性别和全科医生实践相匹配的无先前癌症的人进行了个体匹配。使用Cox模型估计结直肠癌幸存者与无癌症个体相比发生急性肾损伤问题的医院诊断风险比值，整体和根据诊断后时间进行分层调整了其他个体因素（结果风险比值）。共有20,340名结直肠癌幸存者与100,058名无癌症个体进行了匹配。与无癌症的人相比，结直肠癌幸存者患急性肾损伤的风险增加（调整后风险比值=2.16；95%置信区间2.05-2.27）。在诊断后的第一年，风险比值最高（调整后风险比值7.47，6.66-8.37），并随时间的推移逐渐减弱，但在诊断后5年后仍存在较高的患急性肾损伤的风险（调整后风险比值=1.26，1.17-1.37）。结直肠癌和AKI之间的关联在年轻人、男性以及存在既往慢性肾脏疾病的人群中更为明显。结直肠癌幸存者在癌症诊断后的几年中患急性肾损伤的风险增加，这表明有必要优先监测、预防和管理这一癌症幸存者群体的肾脏问题。© 2023. BioMed Central Ltd., part of Springer Nature.

Colorectal cancer survival has improved in recent decades but there are concerns that survivors may develop kidney problems due to adverse effects of cancer treatment or complications of the cancer itself. We quantified the risk of acute kidney injury (AKI) in colorectal cancer survivors compared to people with no prior cancer.Retrospective matched cohort study using electronic health record primary care data from the Clinical Practice Research Datalink GOLD linked to hospital data in England (HES-APC). Individuals with colorectal cancer between 1997-2018 were individually matched on age, sex, and GP practice to people with no prior cancer. We used Cox models to estimate hazard ratios for an incident hospital diagnosis of AKI in colorectal cancer survivors compared to individuals without cancer, overall and stratified by time since diagnosis adjusted for other individual-level factors (adj-HR).Twenty thousand three hundred forty colorectal cancer survivors were matched to 100,058 cancer-free individuals. Colorectal cancer survivors were at increased risk of developing AKI compared to people without cancer (adj-HR = 2.16; 95%CI 2.05-2.27). The HR was highest in the year after diagnosis (adj-HR 7.47, 6.66-8.37), and attenuated over time, but there was still increased AKI risk > 5 years after diagnosis (adj-HR = 1.26, 1.17-1.37). The association between colorectal cancer and AKI was greater for younger people, men, and those with pre-existing chronic kidney disease.Colorectal cancer survivors were at increased risk of AKI for several years after cancer diagnosis, suggesting a need to prioritise monitoring, prevention, and management of kidney problems in this group of cancer survivors.© 2023. BioMed Central Ltd., part of Springer Nature.