X射线互补家族：连接DNA损伤修复与癌症的桥梁。
X-ray cross-complementing family: the bridge linking DNA damage repair and cancer.
发表日期：2023 Sep 07
作者：
Qiang Liu, Qiu Peng, Bin Zhang, Yueqiu Tan
来源：
Cellular & Molecular Immunology
摘要：
基因组不稳定是人类肿瘤的普遍特点。作为遗传信息的携带者，DNA 不断受到各种有害因素的威胁，如果不能及时修复，就会影响遗传信息的传递，导致细胞的癌变。为应对这些威胁，细胞进化出一系列 DNA 损伤应答机制，包括 DNA 损伤修复，以维持基因组的稳定。X光修复互补基因家族(XRCC) 是一类重要的 DNA 损伤修复基因，编码的蛋白质在 DNA 单链断裂和 DNA 碱基损伤修复中发挥重要作用。XRCC 基因家族的功能失调与各种肿瘤的发展有关。在肿瘤的背景下，XRCC 基因及其异常表达导致 DNA 损伤修复异常，从而促进肿瘤细胞的恶性进展。在本文综述中，我们总结了 XRCC 在不同类型肿瘤中扮演的重要角色。此外，我们还讨论了 XRCC 家族成员与肿瘤治疗敏感性之间的相关性。© 2023. BioMed Central Ltd., part of Springer Nature.
Genomic instability is a common hallmark of human tumours. As a carrier of genetic information, DNA is constantly threatened by various damaging factors that, if not repaired in time, can affect the transmission of genetic information and lead to cellular carcinogenesis. In response to these threats, cells have evolved a range of DNA damage response mechanisms, including DNA damage repair, to maintain genomic stability. The X-ray repair cross-complementary gene family (XRCC) comprises an important class of DNA damage repair genes that encode proteins that play important roles in DNA single-strand breakage and DNA base damage repair. The dysfunction of the XRCC gene family is associated with the development of various tumours. In the context of tumours, mutations in XRCC and its aberrant expression, result in abnormal DNA damage repair, thus contributing to the malignant progression of tumour cells. In this review, we summarise the significant roles played by XRCC in diverse tumour types. In addition, we discuss the correlation between the XRCC family members and tumour therapeutic sensitivity.© 2023. BioMed Central Ltd., part of Springer Nature.