肿瘤血管生成是新血管形成以支持肿瘤生长的过程。这个过程对肿瘤的进展和转移至关重要，使之成为一种有吸引力的癌症治疗方法。植物、动物或微生物衍生的天然产物具有抗血管生成特性，可用于抑制肿瘤的生长和进展。在本综述中，我们全面报道了截至2023年3月抗肿瘤血管生成天然产物的最新研究进展，从以下四个角度进行了详细阐述：1）肿瘤血管生成中促血管生成因子和抗血管生成因子的作用；2）抗肿瘤血管生成疗法（单克隆抗体、靶向VEGFR的小分子和融合蛋白）的发展；3）抗血管生成天然物质（包括多酚、多糖、生物碱、萜类化合物、皂苷）及其作用机制的总结；4）抗血管生成天然产物的未来展望（生物利用度提高、剂量和副作用的测试、联合使用以及发现独特的天然产物化合物）。我们的综述旨在更好地了解天然产物在抑制肿瘤血管生成方面的潜力，进一步有助于这些成果有效地过渡到临床试验。本文受版权保护，版权所有。

Tumor angiogenesis is the formation of new blood vessels to support the growth of a tumor. This process is critical for tumor progression and metastasis, making it an attractive approach to cancer therapy. Natural products derived from plants, animals, or microorganisms exert anti-angiogenic properties and can be used to inhibit tumor growth and progression. In this review, we comprehensively report on the current status of natural products against tumor angiogenesis from four perspectives until March 2023: 1) the role of pro-angiogenic factors and antiangiogenic factors in tumor angiogenesis; 2) the development of anti-tumor angiogenesis therapy (monoclonal antibodies, VEGFR-targeted small molecules, and fusion proteins); 3) the summary of anti-angiogenic natural agents, including polyphenols, polysaccharides, alkaloids, terpenoids, saponins and their mechanisms of action; 4) the future perspectives of anti-angiogenic natural products (bioavailability improvement, testing of dosage and side effects, combination use, and discovery of unique natural-based compounds). Our review aims to better understand the potential of natural products for drug development in inhibiting tumor angiogenesis and further aid the effective transition of these outcomes into clinical trials.This article is protected by copyright. All rights reserved.