肿瘤发展与复杂的肿瘤微环境密切相关，该环境包括肿瘤细胞、血管、肿瘤基质细胞、浸润的免疫细胞以及相关效应分子。T辅助17细胞（Th17细胞）是CD4+ T细胞的亚群，以对抗细菌和真菌感染、介导炎症反应的能力而闻名，并表现出依赖环境的效应功能。在肿瘤微环境中，不同的分子信号调控Th17细胞的增殖、分化、代谢重编程和表型转换。因此，Th17细胞对肿瘤的进展有双重影响，可以促进或抑制肿瘤生长。本综述旨在研究肿瘤微环境中各种改变对Th17细胞的抗肿瘤和促肿瘤效应的影响，为探索额外的肿瘤免疫疗法策略提供有价值的线索。© 2023 Xing, Man, Liu, Zhang and Peng.

Tumor development is closely associated with a complex tumor microenvironment, which is composed of tumor cells, blood vessels, tumor stromal cells, infiltrating immune cells, and associated effector molecules. T helper type 17 (Th17) cells, which are a subset of CD4+ T cells and are renowned for their ability to combat bacterial and fungal infections and mediate inflammatory responses, exhibit context-dependent effector functions. Within the tumor microenvironment, different molecular signals regulate the proliferation, differentiation, metabolic reprogramming, and phenotypic conversion of Th17 cells. Consequently, Th17 cells exert dual effects on tumor progression and can promote or inhibit tumor growth. This review aimed to investigate the impact of various alterations in the tumor microenvironment on the antitumor and protumor effects of Th17 cells to provide valuable clues for the exploration of additional tumor immunotherapy strategies.Copyright © 2023 Xing, Man, Liu, Zhang and Peng.