量化低产出手术的比例，定义为病理学上不存在高级别异型前病变或T1N0M0胰腺癌的手术，在胰腺癌监测中。全球范围内在胰腺癌监测方面已经做出了努力，旨在预测高危人群（HRI）中胰腺癌的早期诊断和提高生存率，这些人群存在遗传易感因素。有关胰腺癌监测中对低级别异型或非肿瘤性疾病进行手术的负面影响尚未被很好地量化。 从2000年1月至2023年7月，对于报道与CAPS目标定义不同的最终诊断的研究进行了系统搜索和流行病学分析。次要研究结果是与CAPS目标匹配的最终诊断比例的综合比例（PROSPERO: #CRD42022300408）。 共纳入了23篇文章，包括5027名患者（中位数109名患者/研究，IQR 251）。低产出手术的综合患病率为2.1% [95%CI 0.9-3.7]，I2 83%)。亚组分析显示，在仅包括不带已知致病变体（PV）的家庭性胰腺癌（FPC）患者的研究中，低产出手术的患病率相对较高，但差异不显著，而对照组患病率为将PV携带者纳入研究的研究。未发现影响因素。总体而言，接受监测的对象中进行胰腺切除手术并含有目标病变的患者的综合患病率为0.8% [95%CI 0.3-1.5]，I2 24%). 时间分析显示，低产出手术的比例在过去几十年中逐渐降低，并稳定在1%左右（亚组差异检验 P<0.01）。 胰腺癌监测期间进行"低产出"手术的风险相对较低，但与接受监测的人员需要进行深入讨论。 版权所有 © 2023 Wolters Kluwer Health, Inc. 保留所有权利。

To quantify the rate of low-yield surgery, defined as no high-grade dysplastic precursor lesions or T1N0M0 pancreatic cancer at pathology, during pancreatic cancer surveillance.Global efforts have been made in pancreatic cancer surveillance to anticipate the diagnosis of pancreatic cancer at an early stage and improve survival in high-risk individuals (HRI) with a hereditary predisposition. The negative impact of pancreatic cancer surveillance when surgery is performed for low-grade dysplasia or a non-neoplastic condition is not well-quantified.A systematic search and prevalence meta-analysis was performed for studies reporting surgery with final diagnoses other than those defined by the CAPS goals from January 2000 to July 2023. The secondary outcome was the pooled proportion of final diagnoses matching the CAPS goals (PROSPERO: #CRD42022300408).Twenty-three articles with 5,027 patients (median 109 patients/study, IQR 251) were included. The pooled prevalence of low-yield surgery was 2.1% [95%CI 0.9-3.7], I2 83%). In the subgroup analysis, this prevalence was non-significantly higher in studies that only included familial pancreatic cancer (FPC) subjects without known pathogenic variants (PV), compared to those enrolling PV carriers. No effect modifiers were found. Overall, the pooled prevalence of subjects under surveillance who had a pancreatic resection that contained target lesions was 0.8% [95%CI 0.3-1.5], I2 24%). The temporal analysis showed that the rate of low-yield surgeries decreased in the last decades and stabilized at around 1% (test for subgroup differences P<0.01).The risk of "low-yield" surgery during pancreatic cancer surveillance is relatively low but should be thoroughly discussed with individuals under surveillance.Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.