胸腔肿瘤广泛切除过程中影响膈神经的呼吸功能障碍案例的详细研究很少。在这类情况下，膈肌功能障碍可能导致潜在的致命呼吸和循环紊乱。因此，及时的诊断和干预非常重要。对于膈肌功能障碍导致的呼吸功能障碍，保守的康复治疗是首选。本文报告3例胸腔肿瘤广泛切除过程中膈神经切除引起的呼吸功能障碍的患者。详细描述了每位患者的膈肌功能障碍诊断方法和治疗措施。本研究强调了呼吸功能障碍治疗中呼吸机支持和物理治疗的作用。还讨论了膈肌功能障碍的诊断及膈神经受累的风险评估。列举了呼吸机支持的方式和参数。本研究提供了胸腔肿瘤广泛切除过程中膈神经切除导致的呼吸功能障碍的诊断和治疗经验。对膈肌功能障碍的及时诊断主要依赖临床表现和影像学检查。保守的康复治疗可以改善或恢复大多数患者的膈肌功能，并延缓或避免手术干预的需要。术前评估膈神经受累的风险在这类情况中非常重要。© 2023年作者。由 Wolters Kluwer Health, Inc. 发布。

Cases of respiratory dysfunction due to phrenic nerve sacrifice during resection of massive mediastinal tumor have rarely been studied in detail. Diaphragmatic dysfunction in such cases can lead to potentially fatal respiratory and circulatory disturbances. Therefore, timely diagnosis and intervention are important. Conservative rehabilitation therapy is the first choice for respiratory dysfunction due to diaphragmatic dysfunction.We present 3 patients with respiratory dysfunction due to phrenic nerve sacrifice during resection of massive mediastinal tumor. The diagnostic methods and therapeutic procedures for diaphragmatic dysfunction for each patient are described in detail. This study highlights the role of ventilator support combined with physical therapy in the treatment of respiratory dysfunction in such cases. The diagnosis of diaphragmatic dysfunction as well as the risk assessment of phrenic nerve involvement are also discussed. The modalities of ventilator support, including modes and parameters, are listed.This study provides experiences of diagnosis and treatment of respiratory dysfunction due to phrenic nerve sacrifice during resection of massive mediastinal tumor. Timely diagnosis of diaphragmatic dysfunction primarily relies on clinical manifestations and radiography. Conservative rehabilitation therapy can improve or restore diaphragmatic function in majority of patients, and avert or delay the need for surgical intervention. Preoperative assessment of the risk of phrenic nerve involvement is important in such cases.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.