血清糖类抗原125（CA125）与各种恶性肿瘤的预后有关，包括卵巢癌和胰腺癌。术前血清CA125水平与肝内胆管癌（ICC）患者生存期之间的关系尚未充分研究。本研究旨在探讨肝切除术后CA125对ICC的预后价值。我们回顾性分析了178例接受肝切除的ICC患者的临床病理数据。进行了接收器操作特征分析，评估血清CA125、α-胎蛋白、癌胚抗原（CEA）和糖类抗原19-9与ICC预后的关系。单因素分析和Cox比例风险模型显示了CA125对ICC患者预后的预测价值。CA125与肿瘤大小、分化程度、包膜情况、肿瘤结节转移分期、复发和CEA相关。单因素分析显示，CA125、性别、肿瘤数量、肿瘤大小、分化程度、手术切缘、肿瘤结节转移分期和CEA是影响ICC患者总生存期和无病生存期的危险因素。Cox比例风险模型显示，术前CA125升高、肿瘤大小大于5cm和R1手术切缘是ICC患者总生存期和无病生存期的独立预后预测因子。CA125对不伴有淋巴结转移并伴有糖类抗原19-9升高水平的不同ICC亚组的预后也具有强大的预测价值。术前血清CA125水平是ICC患者术后预后的非侵入性、简单可靠的指标。版权所有©2023作者。由Wolters Kluwer Health, Inc.出版。

Serum carbohydrate antigen 125 (CA125) is associated with the prognosis of various malignancies, including ovarian and pancreatic cancer. The relationship between preoperative serum CA125 level and the survival of patients with intrahepatic cholangiocarcinoma (ICC) has not been fully studied. The aim of this study was to explore the prognostic value of CA125 in ICC after hepatectomy. We retrospectively reviewed the clinicopathological data of 178 ICC patients who underwent hepatic resection. Receiver operating characteristic analyses were performed to estimate the relationships of serum CA125, α-fetoprotein, carcinoembryonic antigen (CEA), and carbohydrate antigen 19-9 with the prognosis of ICC. The predictive value of CA125 for the prognosis of ICC patients was demonstrated by univariate analyses and Cox proportional hazards models. CA125 was correlated with tumor size, differentiation, capsulation, tumor node-metastasis stage, recurrence, and CEA. Univariate analysis indicated that CA125, sex, tumor number, tumor size, differentiation, surgical resection margin, tumor node metastasis stage, and CEA were risk factors for both the overall survival and the disease-free survival of ICC patients. Cox proportional hazards models showed that preoperative elevated CA125, a tumor size > 5 cm, and an R1 surgical resection margin were independent prognostic predictors of overall survival and disease-free survival. CA125 also had strong predictive value for the prognosis of different ICC subgroups, including patients without lymph node metastasis and with elevated carbohydrate antigen 19-9 levels. Preoperative elevated serum CA125 level is a noninvasive, simple, and reliable indicator of the prognosis of ICC patients after hepatectomy.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.