骨肿瘤切除后的大骨缺损的修复和重建仍然是一个巨大的临床挑战。目前，骨科植入物重建是修复骨缺损的主流治疗方法。然而，根据临床反馈，局部肿瘤复发和骨移植不愈合是导致骨缺损修复和重建失败的常见原因，严重危及患者的身心健康。在此基础上，选择自主研制的低模量Ti-12Mo-10Zr合金(TMZ)作为基底材料。为了改善其生物活性和骨整合性能，通过微弧氧化法 (MAO) 在TMZ合金上制备了含有钙、氧和磷的共掺杂微孔设计。然后，将黑磷 (BP) 纳米片结合到MAO处理过的TMZ合金上以获得多功能复合材料。所得到的BP-MAO-TMZ植入体在808 nm近红外激光照射下表现出优异的光热效应和对骨肉瘤癌细胞的有效消融作用，而TMZ合金没有观察到光热或治疗效应。同时，经过MAO处理后获得的结构/成分仿生涂层以及BP纳米片结合后的P驱动原位生物矿化性能赋予BP-MAO-TMZ植入体对MC3T3-E1成骨细胞的活性、增殖和分化能力具有协同促进效果。本研究有望为骨肿瘤患者的手术切除后的骨再生困难和肿瘤复发等问题提供有效的临床解决方案，并解决恶性骨肿瘤患者预后不佳、术后生活质量差等一系列医学问题。© 2023. 作者（们）, 独立授权给Springer Nature B.V.

The repair and reconstruction of large bone defects after bone tumor resection is still a great clinical challenge. At present, orthopedic implant reconstruction is the mainstream treatment for repairing bone defects. However, according to clinical feedback, local tumor recurrence and nonunion of bone graft are common reasons leading to the failure of bone defect repair and reconstruction after bone tumor resection, which seriously threaten the physical and mental health of patients. On this basis, here the self-developed low modulus Ti-12Mo-10Zr alloy (TMZ) was chosen as substrate material. To improve its biological activity and osteointegration, calcium, oxygen, and phosphorus co-doped microporous coating was prepared on TMZ alloy by microarc oxidation (MAO). Then, black phosphorus (BP) nanosheets were incorporated onto MAO treated TMZ alloy to obtain multifunctional composites. The obtained BP-MAO-TMZ implant exhibited excellent photothermal effects and effective ablation of osteosarcoma cancer cells under the irradiation of 808 nm near infrared laser, while no photothermal or therapeutic effects were observed for TMZ alloy. Meanwhile, the structure/component bionic coating obtained after MAO treatment as well as the P-driven in situ biomineralization performance after incorporation of BP nanosheets endowed BP-MAO-TMZ implant with synergistic promoting effect on MC3T3-E1 osteoblasts' activity, proliferation and differentiation ability. This study is expected to provide effective clinical solutions for problems of difficult bone regeneration and tumor recurrence after tumor resection in patients with bone tumors and to solve a series of medical problems such as poor prognosis and poor postoperative quality of patients life with malignant bone tumors.© 2023. The Author(s), under exclusive licence to Springer Nature B.V.