使用68Ga-PSMA-11 PET/CT非侵入性验证微小眼内前列腺癌转移的方法
Noninvasive Verification of a Very Small Intraocular Prostate Carcinoma Metastasis by 68Ga-PSMA-11 PET/CT.
发表日期：2023 Oct 01
作者：
Ferdinand Ndum, Philipp Seifert, Martin Freesmeyer, Falk Gühne
来源：
CLINICAL NUCLEAR MEDICINE
摘要：
一名男性患者接受了68Ga-PSMA-11 PET/CT检查，以评估右眼可疑的眼内转移病灶。虽然脉络膜增厚非常小（4 × 2毫米），而眼底检查和MRI结果均无法确定，PET/CT成像显示可疑病灶中明显表达PSMA，确认为前列腺癌转移。专用的PSMA配体PET/CT成像技术证明了其在检测小的转移病灶上的能力，即使使用68Ga标记的配体也可以。因此，可以避免进一步的侵入性诊断程序。因此，在常规PET/CT成像中应考虑到前列腺癌眼内转移的可能性。
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A male patient underwent 68Ga-PSMA-11 PET/CT for the evaluation of a suspected intraocular metastasis in the right eye. Although the choroidal thickening was very small (4 × 2 mm), and ophthalmoscopy as well as MRI were inconclusive, PET/CT imaging showed distinct PSMA expression in the suspected lesion, confirming prostate cancer metastasis. The ability of dedicated PSMA ligand PET/CT imaging to detect small metastases, even with 68Ga-labeled ligands, has been demonstrated. Therefore, the use of further invasive diagnostic procedures could be avoided. Thus, the possibility of detecting intraocular metastases of prostate cancer should be considered in routine PET/CT imaging.Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.