由于对人类健康的危害，特别细颗粒物（PM2.5）已成为中国的一项重要公共卫生问题。本研究旨在研究PM2.5污染对中国导致的全因和特定于原因的死亡负担的趋势。我们提取了1990年至2019年中国的PM2.5暴露所致的全因和特定于原因的死亡数据，数据来源于《全球负担疾病2019年报告》。利用Joinpoint回归程序计算了由于PM2.5暴露引起的标准化死亡率（ASMR）和失年寿命（YLLs）的平均年度百分比变化（AAPC）。利用Pearson相关性分析，我们估计了负担趋势、城市绿地面积和高等教育比例之间的关联。 在1990年至1999年期间，所有原因（1.6%，95% CI：1.5%至1.8%）、糖尿病（5.2%，95% CI：4.9%至5.5%）、脑炎（3.1%，95% CI：2.6%至3.5%）、缺血性心脏病（3.3%，95% CI：3%至3.6%）和气管、支气管和肺癌（5%，95% CI：4.7%至5.2%）的死亡率都有增长。在2010年至2019年期间，糖尿病的死亡率仍有增加，但增速较低，AAPC为1.2%（95% CI：1%至1.4%）。而气管、支气管和肺癌在该期间的增长较小，AAPC为0.5%（95% CI：0.3%至0.6%）。在YLLs方面，趋势似乎相似。 我们的研究结果强调了中国PM2.5导致的疾病负担的增加趋势，尤其是糖尿病、气管、支气管和肺癌。 版权所有：© 2023 刘，燕。本文是一篇开放获取文章，根据知识共享署名许可协议发表，允许在任何媒体中自由使用、分发和再现，前提是原作者和出处得到了认可。

Particularly fine particulate matter (PM2.5) has become a significant public health concern in China due to its harmful effects on human health. This study aimed to examine the trends in all causes and cause specific morality burden attributable to PM2.5 pollution in China.We extracted data on all causes and cause specific mortality data attributable to PM2.5 exposure for the period 1990-2019 in China from the Global Burden of Disease 2019. The average annual percent change (AAPC) in age-standardized mortality rates (ASMR) and years of life lost (YLLs) due to PM2.5 exposure were calculated using the Joinpoint Regression Program. Using Pearson's correlation, we estimated association between burden trends, urban green space area, and higher education proportions.During the period 1990-1999, there were increases in mortality rates for All causes (1.6%, 95% CI: 1.5% to 1.8%), Diabetes mellitus (5.2%, 95% CI: 4.9% to 5.5%), Encephalitis (3.1%, 95% CI: 2.6% to 3.5%), Ischemic heart disease (3.3%, 95% CI: 3% to 3.6%), and Tracheal, bronchus and lung cancer (5%, 95% CI: 4.7% to 5.2%). In the period 2010-2019, Diabetes mellitus still showed an increase in mortality rates, but at a lower rate with an AAPC of 1.2% (95% CI: 1% to 1.4%). Tracheal bronchus and lung cancer showed a smaller increase in this period, with an AAPC of 0.5% (95% CI: 0.3% to 0.6%). In terms of YLLs, the trends appear to be similar.Our findings highlight increasing trends in disease burden attributable to PM2.5 in China, particularly for diabetes mellitus, tracheal, bronchus, and lung cancer.Copyright: © 2023 Liu, Yan. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.