间充质干细胞（mesenchymal stem cell，MSC）来源的外泌体在退行性疾病中的病理学和治疗学作用；尤其关注长链非编码RNA和微小RNA。
The pathological and therapeutically role of mesenchymal stem cell (MSC)-derived exosome in degenerative diseases; Particular focus on LncRNA and microRNA.
发表日期：2023 Aug 22
作者：
Aiman Mohammed Baqir Al-Dhalimy, Haitham Mukhlif Salim, A H Shather, Israa Habeeb Naser, Manar Mohammed Hizam, Mohannd Kadhim Alshujery
来源：
Cellular & Molecular Immunology
摘要：
通过释放出可促进炎症解除的理想环境的外泌体，间充质干细胞（MSCs）增强了组织修复并具有强大的免疫调节能力。MSCs来源的外泌体还可通过多种机制影响肿瘤进展。外泌体作为一种细胞间通信工具，可以影响受体细胞的细胞活动，并包含一系列高效的生物活性化学物质。理解炎症消除、组织稳态维持和治疗策略的基本生物学特性对于外泌体长非编码RNA（lncRNA）和微RNA（miRNA）在受体细胞中的水平转移以影响靶基因表达来讲尤为重要。在此提出了神经、肾脏、心脏、肺部、肝脏疾病以及皮肤伤口和关节炎中的外泌体lncRNA和miRNA谱。版权所有 © 2023 Elsevier GmbH。保留所有权利。
By releasing exosomes, which create the ideal milieu for the resolution of inflammation, mesenchymal stem cells (MSCs) enhance tissue healing and have strong immunomodulatory capabilities. MSCs-derived exosome also can affect tumor progress by a myriad of mechanisms. Exosomes function as a cell-cell communication tool to affect cellular activity in recipient cells and include an array of efficient bioactive chemicals. Understanding the fundamental biology of inflammation ablation, tissue homeostasis, and the creation of therapeutic strategies is particularly interested in the horizontal transfer of exosomal long non-coding RNAs (lncRNA) and microRNAs (miRNAs) to recipient cells, where they affect target gene expression. Herein, we propose an exosomal lncRNA and microRNA profile in neurological, renal, cardiac, lung, and liver diseases as well as skin wounds and arthritis.Copyright © 2023 Elsevier GmbH. All rights reserved.