肿瘤内异质性的汇合见解。
Convergent insights into intratumor heterogeneity.
发表日期：2023 Sep 06
作者：
Claudia Manini, Annick Laruelle, André Rocha, José I López
来源：
Trends in Cancer
摘要：
通过数学、传统组织学和基因组学的结合，证实高度侵袭性透明细胞肾细胞癌（CCRCC）表现出较低水平的肿瘤内异质性（ITH）。我们假设，旨在保持较高ITH水平的治疗策略将有助于减缓癌症演化并改善生存。版权所有© 2023 Elsevier Inc. 保留所有权利。
Mathematics, conventional histology, and genomics converge to confirm that highly aggressive clear cell renal cell carcinomas (CCRCCs) display low levels of intratumor heterogeneity (ITH). We hypothesize that therapeutic strategies aimed at maintaining high ITH levels would be advisable to slow down cancer evolution and to improve survival.Copyright © 2023 Elsevier Inc. All rights reserved.