肠道菌群与癌症治疗不良反应的发育和进展之间的关联。
The Association between the Gut Microbiome and Development and Progression of Cancer Treatment Adverse Effects.
发表日期：2023 Aug 28
作者：
Amanda S Maddern, Janet K Coller, Joanne M Bowen, Rachel J Gibson
来源：
BIOMEDICINE & PHARMACOTHERAPY
摘要：
细胞毒性抗癌治疗的不良反应是常见的后果。在过去的20年里，针对肠道菌群和这些不良反应之间的关系进行了重要的探索。多个临床研究表明，肠道菌群的变化与急性胃肠道不良反应的发展相关。这些反应包括腹泻和粘膜炎。然而，最新的研究表明，肠道菌群的变化也可能与长期发展的心理神经变化、癌症消瘦和疲劳相关。因此，本综述的目的是通过检视文献，确定肠道菌群与细胞毒性抗癌治疗的广泛不良反应之间可能的贡献和关联。
Adverse effects are a common consequence of cytotoxic cancer treatments. Over the last two decades there have been significant advances in exploring the relationship between the gut microbiome and these adverse effects. Changes in the gut microbiome were shown in multiple clinical studies to be associated with the development of acute gastrointestinal adverse effects, including diarrhoea and mucositis. However, more recent studies showed that changes in the gut microbiome may also be associated with the long-term development of psychoneurological changes, cancer cachexia, and fatigue. Therefore, the aim of this review was to examine the literature to identify potential contributions and associations of the gut microbiome with the wide range of adverse effects from cytotoxic cancer treatments.