智能纳米级胞外囊泡在癌症治疗中的潜在治疗诊断应用：在胃肠肿瘤中的潜力治疗与诊断应用。
Smart nano-sized extracellular vesicles for cancer therapy: potential theranostic applications in gastrointestinal tumors.
发表日期：2023 Sep 08
作者：
Donatella Lucchetti, Filomena Colella, Giulia Artemi, Shafiul Haque, Alessandro Sgambato, Rinaldo Pellicano, Sharmila Fagoonee
来源：
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
摘要：
细胞外囊泡（EVs）因其小尺寸、生物分子载荷、介导细胞间通讯的能力、高物理化学稳定性、低免疫原性和生物相容性，在寻找包括癌症在内的一系列病理治疗的下一代治疗方法方面获得了巨大的兴趣。采用多种策略增强了EVs的治疗诊断潜力，包括基因或代谢工程、母细胞修饰或直接功能化，将治疗化合物纳入这些纳米平台。智能纳米尺寸的EVs在癌症领域提供了巨大的机会，目前的研究已着眼于克服现有的缺点。尽管面临挑战，智能EVs已经在临床中得到了应用。在这里，我们更新了用于EV功能化的技术，以实现最佳肿瘤细胞定位和体内EV追踪，同时结合生物成像模式，并提供了在胃肠肿瘤背景下利用这些改良的EVs进行的临床前和临床研究的最新资讯。版权所有 © 2023 Elsevier B.V. 发布。
Extracellular vesicles (EVs) have gained tremendous interest in the search for next-generation therapeutics for the treatment of a range of pathologies, including cancer, especially due to their small size, biomolecular cargo, ability to mediate intercellular communication, high physicochemical stability, low immunogenicity and biocompatibility. The theranostic potential of EVs have been enhanced by adopting several strategies such as genetic or metabolic engineering, parental cell modification or direct functionalization to incorporate therapeutic compounds into these nanoplatforms. The smart nano-sized EVs indeed offer huge opportunities in the field of cancer, and current research is set at overcoming the existing pitfalls. Smart EVs are already being applied in the clinics despite the challenges faced. We provide, herein, an update on the technologies employed for EV functionalization in order to achieve optimal tumor cell targeting and EV tracking in vivo with bio-imaging modalities, as well as the preclinical and clinical studies making use of these modified EVs, in the context of gastrointestinal tumors.Copyright © 2023. Published by Elsevier B.V.