烷醇类化合物的抗癌作用的分子靶点和机制。
Molecular targets and mechanisms of anti-cancer effects of withanolides.
发表日期：2023 Sep 08
作者：
Zhiruo Zhang, Yueying Yang, Yang Xu, Yang Liu, Hua Li, Lixia Chen
来源：
Cellular & Molecular Immunology
摘要：
哪些维斯甘酯是一类具有类固醇内酯结构的天然产物，表现出广谱的抗癌效果。迄今为止，已有多项研究表明，维斯甘酯在癌症发展和进展过程中的机制可能与细胞增殖、凋亡、转移和血管生成等调节有关。维斯甘酯还能减弱炎症反应，调控癌细胞的基因组不稳定和能量代谢。此外，它们还可以作为传统癌症治疗的辅助药物，改善治疗的安全性和疗效。在这里，我们总结了维斯甘酯在不同癌症中的分子靶点和机制，以及当前对它们的临床研究。版权所有 © 2023 Elsevier B.V. 发表。
Withanolides are a class of natural products with a steroidal lactone structure that exhibit a broad spectrum of anti-cancer effects. To date, several studies have shown that their possible mechanisms in cancer development and progression are associated with the regulation of cell proliferation, apoptosis, metastasis, and angiogenesis. Withanolides can also attenuate inflammatory responses, as well as modulate the genomic instability and energy metabolism of cancer cells. In addition, they may improve the safety and efficacy of cancer treatments as adjuvants to traditional cancer therapeutics. Herein, we summarize the molecular targets and mechanisms of withanolides in different cancers, as well as their current clinical studies on them.Copyright © 2023. Published by Elsevier B.V.