年仅9岁女童成功接受新型手术技术和骨移植治疗的巨大软骨肉瘤:病例报告。
Large chondrosarcoma treated successfully with new surgical technique and bone grafts in a 9-year-old girl: Case report.
发表日期:2023 Sep 03
作者:
Bakri Roumi Jamal, Qusai Razzouk, Mohammed Al-Mahdi Al-Kurdi, Othman Sheikh Hussein, Hani Alloush
来源:
Bone & Joint Journal
摘要:
软骨肉瘤位列骨肉瘤之后的第二常见类型,主要影响成年人和老年人,主要出现在骨盆和近端股骨。疼痛和病理性骨折是常见症状。该肿瘤对放射治疗和化疗具有抵抗力,手术切除是最有效的治疗方法。9岁女孩出现左大腿不明疼痛。体格检查和影像学显示大腿有多个溶骨性病灶,活检证实为典型软骨肉瘤。患者接受手术,手术包括切除肿瘤并保留安全间隙,采用Z形成术技术。合成骨移植颗粒填充切除区域。患者经过8年的随访,没有并发症和复发。软骨肉瘤根据组织学特征和临床表现进行分类。软骨肉瘤对化疗和放射治疗具有抵抗力。治疗选择取决于肿瘤的特征,可能需要进行重建手术。对于长骨的低级别软骨肉瘤,通常采用肿瘤内切除和刮除,但可能需要广泛切除以减小复发的可能性。血管化腓骨自体移植有承载重量的潜力,但可能出现骨折和供体部位的并发症。异体移植重建可能与感染、骨折、延迟或不愈合有关。治疗方法根据肿瘤分期、等级和位置的因素而不同。每种方法都有自己的风险和并发症,包括感染、骨折和延迟愈合。本研究提出了一种使用骨移植的新手术技术。
版权所有© 2023作者。由Elsevier Ltd.出版。保留所有权利。
Chondrosarcoma is the second most common after osteosarcoma. It mostly effects adults and elderly individuals, primarily seen in the pelvic and proximal femoral bone. Pain and pathological fractures are common symptoms. The tumor is resistant to radiotherapy and chemotherapy, so surgical excision is the most effective treatment.A 9-year-old girl presented with vague pain in her left thigh. Physical examination and imaging revealed multiple osteolytic lesions in the thigh, and a biopsy confirmed classical chondrosarcoma. The patient underwent surgery, which involved excision of the tumor with a safety margin and the use of a Z-plasty technique. Synthetic graft granules were used to fill the excision area. The patient was followed-up over 8 years without complications and recurrence.Chondrosarcoma is classified based on histological characteristics and clinical behavior. Chondrosarcoma is resistant to chemotherapy and radiation. Treatment options depend on tumor characteristics, and reconstruction may be necessary. For low-grade chondrosarcomas in long bones, intralesional excision and curettage are commonly used, but wide excision may be necessary to minimize recurrence. Vascularized fibular autografts have the potential for weight-bearing, but complications such as fractures and donor site morbidity can occur. Allograft reconstruction may be associated with infection, fracture, delayed or nonunion.Treatment approaches vary based on factors such as tumor stage, grade, and location. Each option carries its own risks and complications, including infection, fracture, and delayed healing. This study suggests a new surgical technique using bone grafts.Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.