失智症是一种神经认知障碍，通常发生在老年患者和晚期癌症患者身上。虽然关于癌症患者中出现失智症的报道很多，但尚无专门针对骨肌肿瘤患者的报道。本前瞻性研究旨在调查骨肌肿瘤患者中失智症的发病率、危险因素和预后意义。本研究纳入了148例骨肌肿瘤肿瘤科患者。估计的危险因素包括年龄、性别、酒精滥用、生活能力状态（PS）、饮食状况、入院途径、肿瘤恶性度、癌症分期和血液检测结果。还检查了失智症对生存的影响。只有18例患有恶性肿瘤的患者出现了失智症（12.2%）。根据单因素分析，年龄较大、生活能力状况差、饮食状况差、来自其他医院的入院、恶性肿瘤、癌症而非肉瘤、贫血和某些实验室异常被发现是失智症的显著危险因素。多因素分析表明，生活能力状态差与失智症显著相关。此外，失智症与预后不良显著相关。骨肌肿瘤患者中失智症的发病率为12.2%，仅在恶性肿瘤患者中观察到。生活能力状态是失智症的一个显著危险因素。失智症与预后不良相关。 ©作者或其雇主2023。基于CC BY-NC许可进行复用。不允许商业复用。由BMJ出版。

Delirium, a neurocognitive disorder, typically occurs in older patients and those with advanced cancer. Although there have been numerous reports on delirium in patients with cancer in various conditions, there are no reports that specifically focus on patients with musculoskeletal tumours. This prospective study aimed to investigate the incidence, risk factors and prognostic implications of delirium in patients with musculoskeletal tumours.In this single institutional study, 148 patients with musculoskeletal oncology were enrolled. The estimated risk factors included age, sex, alcohol abuse, performance status (PS), dietary status, admission route, tumour malignancy, oncological stage and blood test results. The significance of delirium in survival was also examined.Only 18 patients with malignant tumours had delirium (12.2%). Based on univariate analysis, older age, poor PS, dietary status, admission from another hospital, malignant tumour, carcinoma rather than sarcoma, anaemia and some laboratory abnormalities were found to be significant risk factors for delirium. Multivariate analysis showed that poor PS was significantly correlated with delirium. Additionally, delirium was significantly correlated with poor survival.The incidence of delirium among patients with musculoskeletal tumours was 12.2% and was observed only in patients with malignant tumours. PS is a significant risk factor for delirium. Delirium is correlated with poor prognosis.© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.