本研究旨在调查三种不同手术方式治疗脑室内颅咽管瘤（IVCs）的治疗效果。本研究调查的三种手术方式分别为内窥镜经鼻腔入路（EEA）、正侧枕前穿刺临时头孔入路（PTA）和两半球沿切迹临时头孔入路（ITA）。病人的人口统计资料、术前症状、内分泌和下丘脑状态、肿瘤特征以及手术结果在不同手术组之间进行分析和比较。分析对象共计31例IVCs患者，其中EEA组12例，ITA组8例，PTA组11例。平均随访时间为39±23个月。数据的统计分析显示，三种手术组的完全切除率（GTR）存在显著差异（P=0.033）。EEA组的GTR率为100%，ITA组为88%，PTA组为64%，是最低的。手术后，EEA组只有8.3%的患者未出现新的术后垂体功能减退，而ITA组和PTA组的比例分别为75%和73%（P=0.012）。最后，我们发现术后垂体功能减退可能与手术中下垂体柄断裂有关（P=0.020）。根据本研究的结果，我们建议在IVCs的手术切除中使用EEA和ITA，而不是PTA。此外，应根据肿瘤的生长模式选择适当的手术方法。© 2023. 作者（按照Springer Nature的授权独家许可）

This study aimed to investigate the therapeutic efficacy of three different surgical approaches for the treatment of intraventricular craniopharyngiomas (IVCs). The three surgical approaches investigated in this study were the endoscopic endonasal approach (EEA), pterional trans-lamina terminalis approach (PTA), and interhemispheric trans-lamina terminalis approach (ITA). Patient demographics, preoperative symptoms, endocrine and hypothalamic status, tumor characteristics, and surgical outcomes were analyzed and compared among the different surgical groups. A total of 31 patients with IVCs were included in the analysis, with 12 patients in the EEA group, 8 patients in the ITA group, and 11 patients in the PTA group. The mean follow-up time was 39 ± 23 months. Statistical analysis of the data revealed significant differences in the gross total resection (GTR) rate among the three surgical groups (P = 0.033). The GTR rate for the EEA group was 100%, that for the ITA group was 88%, and that for the PTA group was 64%, which was the lowest rate observed. After surgery, only 8.3% of the patients in the EEA group did not experience new postoperative hypopituitarism, while the percentages in the ITA and PTA groups were 75% and 73%, respectively (P = 0.012). Finally, we found that postoperative hypopituitarism may be related to the transection of the pituitary stalk during the operation (P = 0.020). Based on the results of this study, we recommend using the EEA and the ITA instead of the PTA for the surgical resection of IVCs. Furthermore, the appropriate surgical approach should be selected based on the tumor's growth pattern.© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.