对TP53密码子72多态性与口腔潜在恶性疾病发病和进展的系统评价。
Systematic evaluation of TP53 codon 72 polymorphism associated with onset and progression of oral potentially malignant disorders.
发表日期：2023 Sep 12
作者：
Huangkai Li, Yu Liu, Shanxin Zhou, Qin Zhou, Xi Yang
来源：
BMC Oral Health
摘要：
最近，一项系统回顾和荟萃分析表明p53免疫蛋白的过度表达与口腔潜在恶性病变（OPMD）的进展风险显著相关。然而，关于OPMD的TP53基因分型的研究结果不一致且无定论。我们进行了一项系统评价，以确定所有符合条件的病例对照研究，研究TP53密码子72多态性与OPMD的发病和进展的关联。共有768例OPMD患者和1173名健康个体从12项符合条件的病例对照研究中确定了与TP53密码子72多态性OPMD发病有关的患者。在总体和亚组分析中，对于包括等位基因C vs. G、纯合子CC vs. GG、杂合子GC vs. GG、显性遗传模型GC+CC vs. GG和隐性遗传模型CC vs. GG+GC在内的遗传模型，观察到OPMD发病风险无显著性（所有P值>0.05）。此外，从8项符合条件的病例对照研究中确定了465例OPMD患者和775例口腔鳞状细胞癌（OSCC）患者，研究了该多态性在OPMD进展为OSCC中的作用。分析结果显示，对于这些遗传模型，OPMD进展风险也无显著性（所有P值>0.05）。我们的数据汇总分析表明，TP53密码子72多态性可能不是OPMD发病和进展的遗传因素。结合系统回顾和荟萃分析得出的结论，我们提出了一个新观点，即TP53基因分型可能不会影响OPMD中p53蛋白的表达。©2023. BioMed Central Ltd., part of Springer Nature.
Recently, a systematic review and meta-analysis demonstrated that overexpression of p53 immunoprotein was significantly associated with progression risk of oral potentially malignant disorders (OPMD). However, the results of investigations on TP53 genetic typing in OPMD were inconsistent and inconclusive.A systematic evaluation was conducted to identify all eligible case-control studies on the association of TP53 codon 72 polymorphism with both onset and progression of OPMD.A total of 768 OPMD patients and 1173 healthy individuals were identified from 12 eligible case-control studies on TP53 codon 72 polymorphism OPMD onset. In overall and subgroup analyses, no significantly risk of OPMD onset was observed in the cases for genetic models including allele C vs. G, homozygote CC vs. GG, heterozygote GC vs. GG, dominant GC + CC vs. GG, and recessive CC vs. GG + GC (all P-value of association test > 0.05). Further, a total of 465 OPMD patients and 775 oral squamous cell carcinoma (OSCC) ones were identified from 8 eligible case-control studies on this polymorphism in OPMD progression to OSCC. The analyses revealed that there was also no significantly risk of OPMD progression in the cases for the genetic models (all P-value of association test > 0.05).Our data of a pooled-analysis indicates that TP53 codon 72 polymorphism may not act as genetic factor for the risk of OPMD onset and progression. Combined with the conclusion by a systematic review and meta-analysis, we put forward a new opinion that TP53 genetic typing cloud not influence p53 protein expression in OPMD.© 2023. BioMed Central Ltd., part of Springer Nature.