本研究旨在评估术前中性粒细胞/白蛋白比值（NAR）对口腔鳞状细胞癌（OSCC）的预后意义。共纳入622例行手术治疗的OSCC患者。NAR定义为术前外周血清中的中性粒细胞计数除以白蛋白水平。采用Cox比例风险模型，探索与生存结果相关的因素。确定了预测总生存（OS）的NAR最佳截断值为0.1。Cox模型中，高NAR独立性地成为OS、癌症特异性生存和无复发生存的负面预后因素（调整风险比分别为1.503、1.958和1.727，所有p值 均小于0.05）。基于NAR的计分表准确预测了OS（一致性指数为0.750）。我们的研究表明，术前NAR是一种方便且有效的口腔鳞状细胞癌预后标志物，并且基于NAR的计分表可以在临床环境中作为一种有前途的预后工具。© 2023 Wiley Periodicals LLC.

We aimed to evaluate the prognostic significance of preoperative neutrophil-to-albumin ratio (NAR) in oral squamous cell carcinoma (OSCC).A total of 622 patients with surgically treated OSCC were enrolled. NAR was defined as the absolute neutrophil count divided by the serum albumin level in peripheral blood before the radical surgery. Cox proportional hazards model were used to discover survival outcome-associated factors.The optimal cut-off of NAR to predict overall survival (OS) was determined to be 0.1. In Cox model, high NAR was identified as an independent negative prognosticator of OS, cancer-specific survival, and recurrence-free survival (adjusted hazard ratio: 1.503, 1.958, and 1.727, respectively; all p < 0.05). The NAR-based nomogram accurately predicted OS (concordance index: 0.750).Our study suggests that preoperative NAR is a convenient and effective prognostic marker for OSCC and NAR-based nomogram can be a promising prognostic tool in clinical setting.© 2023 Wiley Periodicals LLC.