髓母细胞瘤是脑肿瘤之一，由于治疗方法的改进，患者的预后有所提高。除了有希望的治疗结果外，也会出现各种不良反应。本研究旨在回顾我们对髓母细胞瘤病例的长期随访结果。该研究评估了2007年至2018年间被诊断为髓母细胞瘤并随访了5年或更久的20例患者的诊断时年龄、髓母细胞瘤的组织学类型、切除范围、化疗和放疗方案、随访时间以及内分泌、神经精神、心脏、听力和视力检查结果。 研究包括了53例患者中的20例。其中11例（55%）为男性。平均诊断年龄为6.95岁，研究时平均年龄为14岁。平均随访时间为8.95年。在手术方面，有14例（70%）为完全切除，1例（5%）为近全切除，2例（10%）为次全切除。在组织病理学检查中，有14例（70%）为典型髓母细胞瘤，4例（20%）为致密性髓母细胞瘤，1例（5%）为不典型髓母细胞瘤。在内分泌评估方面，15例（75%）患者出现甲状腺功能减低，5例（25%）出现生长激素缺乏，7例（35%）有临床上的生长激素缺乏，5例（25%）出现性激素失调。在神经精神检查中，11例（55%）患者有神经后遗症，18例（90%）患者出现精神问题，14例（70%）患者同时存在两个或更多神经精神问题。1例（5%）患者出现二尖瓣关闭不全。12例患者（60%）有听力损失。根据视力检查结果，6例（30%）患者出现屈光不正，4例（20%）患者出现白内障，1例（5%）患者出现干眼症。 对髓母细胞瘤患者的长期副作用进行仔细监测对于改善患者的生活质量至关重要。除了疾病和治疗的内分泌和其他身体遗症外，增加的神经精神问题也表明，在治疗儿童髓母细胞瘤时，仅仅治愈并不是唯一的问题。 © 2023年。该作者授权Springer-Verlag GmbH Germany独家发表，属于Springer Nature。

Medulloblastoma is one of the brain tumors with increased life expectancy due to improvements in treatment approaches. Besides the promising results, various undesirable effects can be encountered. This study's aim is to review long-term follow-up outcomes of our cases with medulloblastoma.Age at diagnosis, histological type of medulloblastoma, resection extension, chemotherapy and radiotherapy schemes, follow-up duration, and endocrinological, neuropsychiatric, cardiological, auditory, and visual examination results were evaluated in 20 patients diagnosed between 2007 and 2018 and followed 5 years and more.Twenty of 53 patients were included to the study. Eleven (55%) were male. Mean age at diagnosis was 6.95 years; mean age at the time of the study was 14 years. Mean follow-up time was 8.95 years. In terms of surgery, 14 (70%) were gross total, 1 (5%) was near total, and 2 (10%) were subtotal resection. In histopathological examination, 14 (70%) were classical medulloblastoma, 4 (20%) were desmoplastic medulloblastoma, and 1 (5%) was anaplastic medulloblastoma. With regard to endocrinological evaluation, 15 (75%) patients had hypothyroidism, 5 (25%) had growth hormone deficiency, 7 (35%) had clinical growth hormone deficiency, and 5 (25%) had sex hormone disorders. In neuropsychiatric examination, 11 (55%) patients had neurological sequelae, 18 (90%) patients had psychiatric issues, and 14 (70%) patients had two or more neuropsychiatric problems simultaneously. One (5%) patient had mitral valve insufficiency. Twelve patients (60%) had hearing loss. According to visual examination, 6 (30%) patients had refraction problem, 4 (20%) had cataract, and 1 (5%) had dry eye.Careful monitoring of long-term side effects is important for improving the quality of life of medulloblastoma patients. Besides endocrinological and other somatic sequelae of the disease and treatment, increased neuropsychiatric problems showed us that only cure is not the issue while treating childhood medulloblastoma.© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.