为了解垂体转移的自然历史和最佳治疗策略，我们进行了本院病例回顾研究和主题综述。回顾研究共纳入了七名患者，平均年龄为59.6岁。主要组织学类型包括乳腺癌（4例）、黑色素瘤（1例）、肾细胞癌（1例）和肉瘤（1例）。两名患者出现前垂体内分泌功能障碍，其中一例是唯一一例出现视觉症状的患者。所有患者均接受了放射外科治疗，其中两例还进行了手术切除。总体生存期范围为6.5至117个月。文献综述共纳入了71项研究的166例患者。最常见的原发癌是肺癌（27.7%），其次是乳腺癌（18.7%）和肾癌（14.5%）。其中107例出现了内分泌功能障碍，其中包括41例尿崩症和55例低垂体功能。110例出现了视觉损害。107例患者接受了放疗，96例患者接受了手术切除，44例患者接受了系统化疗/免疫疗法。手术与视力改善的可能性呈显著关联，而与内分泌正常化的可能性呈负相关。放射影像学缩小预示着视力改善。中位总生存期为9.9个月（范围：0.2-96）。这次主题综述表明，放射外科和手术切除两种方法已经广泛应用于治疗垂体转移，并获得了良好的反应。手术切除后视力改善的可能性更大，但可能以内分泌功能障碍为代价。尽管治疗和影像学反应，患者的生存期仍不足一年。© 2023年 作者，独家授权给施普林格科学+商业传媒有限责任公司，施普林格自然出版集团的一部分。

To understand the natural history and optimal treatment strategy for pituitary gland metastasis.We performed both a retrospective chart review of patients treated at our institution and a scoping review of the topic.The retrospective review identified seven patients with an average age of 59.6 years. Primary histologies included breast cancer (4), melanoma (1), renal cell carcinoma (1), and sarcoma (1). Two patients had anterior pituitary endocrine dysfunction, one of whom was the only patient with visual symptoms. All patients were treated with radiosurgery and two also underwent surgical resection. Overall survival ranged from 6.5 to 117 months. Literature review identified 166 patients from 71 studies. The most common primary cancer was lung (27.7%), followed by breast (18.7%) and renal (14.5%) cancer. 107 presented with endocrine dysfunction, including 41 cases of diabetes insipidus and 55 cases of hypopituitarism. 110 presented with visual compromise. 107 patients received radiotherapy, 96 underwent surgical resection and 44 received systemic chemotherapy/immunotherapy. Surgery was significantly associated with an increased likelihood of vision improvement and a decreased likelihood of endocrine normalization. Radiographic regression predicted visual improvement. Median overall survival was 9.9 months (range: 0.2-96).This scoping review showed that both radiosurgery and surgical resection have been frequently used to treat pituitary metastases with good response. Vision improvement is more likely to happen following surgical resection, likely at the expense of endocrine dysfunction. Despite treatment and radiographic response, patient survival remains less than a year.© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.