胶质母细胞瘤（GBM）是一种中枢神经系统的毁灭性肿瘤，目前缺乏有效的治疗方法。治疗的黄金标准是手术切除后进行化疗（通常是使用替莫唑胺，TMZ）和/或放疗。然而，由于化疗耐药性的发展和系统性给药的重度副作用，TMZ在完成治疗后并未提供显著的生存益处。迫切需要改进传统治疗和辅助疗法，以提高患者的生存率和生活质量。刺激响应型基于脂质的药物递送系统提供了克服当前治疗局限性的有希望前景。在这项研究中，多功能脂质基磁性纳米载体（Ang-TMZ-LMNVs），功能化肽Angiopep-2并装载有TMZ，被用于在体内模型中增强特定的GBM治疗。暴露于交替磁场（AMFs）下使得磁致热疗法得以进行，与化疗药物协同作用。对裸鼠正柄人类U-87 MG-Luc2肿瘤的研究表明，Ang-TMZ-LMNVs可以在局部给药后在肿瘤中积累并保留，而不穿越到健康组织，有效地抑制肿瘤侵袭和增殖，并与AMF刺激结合显著延长中位生存时间。这种强大的协同方法已被证明是一种强大而多功能的纳米平台，用于有效治疗GBM。

Glioblastoma multiforme (GBM) is a devastating tumor of the central nervous system, currently missing an effective treatment. The therapeutic gold standard consists of surgical resection followed by chemotherapy (usually with temozolomide, TMZ) and/or radiotherapy. TMZ does not, however, provide significant survival benefit after completion of treatment because of development of chemoresistance and of heavy side effects of systemic administration. Improvement of conventional treatments and complementary therapies are urgently needed to increase patient survival and quality of life. Stimuli-responsive lipid-based drug delivery systems offer promising prospects to overcome the limitations of the current treatments. In this work, multifunctional lipid-based magnetic nanovectors functionalized with the peptide angiopep-2 and loaded with TMZ (Ang-TMZ-LMNVs) were tested to enhance specific GBM therapy on an in vivo model. Exposure to alternating magnetic fields (AMFs) enabled magnetic hyperthermia to be performed, that works in synergy with the chemotherapeutic agent. Studies on orthotopic human U-87 MG-Luc2 tumors in nude mice have shown that Ang-TMZ-LMNVs can accumulate and remain in the tumor after local administration without crossing over into healthy tissue, effectively suppressing tumor invasion and proliferation and significantly prolonging the median survival time when combined with the AMF stimulation. This powerful synergistic approach has proven to be a robust and versatile nanoplatform for an effective GBM treatment.