白蛋白/碱性磷酸酶比值（AAPR）是一种新发展的血液生物标志物，据报道在多种癌症中具有预后价值。本研究的目的是调查AAPR在行根治性结直肠癌手术后总体生存率中的预测价值，研究对象为I-III期结直肠癌患者。对221例符合条件的I-III期结直肠癌患者的临床数据进行了回顾性分析。进行一系列生存分析，以评估AAPR的预后价值。进行单因素和多因素Cox分析，以确定独立的风险因素。基于AAPR等独立的风险因素进一步构建了柱状图预测模型，并验证了其预测性能。根据单因素和多因素Cox回归分析结果显示，术前AAPR对于行腹腔镜下根治性结直肠癌手术后总体生存（OS）的最佳截断值为0.495。年龄≤65岁、TNM分期I-II期、肿瘤分级（高/中分化）、CEA≤5和AAPR≥0.495与较好的OS相关（P < .05）。术前AAPR水平是行腹腔镜下根治性结直肠癌手术后生存的良好预测因子，AAPR <0.495是降低术后OS的独立风险因素。

The albumin to alkaline phosphatase ratio (AAPR) is a newly developed blood biomarker that has been reported to have prognostic value in several types of cancers. The aim of this study was to investigate the predictive value of AAPR in overall survival after radical colon cancer surgery in patients with stage I-III colorectal cancer (CRC).The clinical data of 221 eligible patients with stage I ∼ III CRC were retrospectively analyzed. A series of survival analyses were performed to assess the prognostic value of AAPR. Univariate and multifactorial Cox analyses were performed to identify independent risk factors. Columnar graph prediction models were further constructed based on independent risk factors such as AAPR, and their predictive properties were validated.The optimal cutoff value of preoperative AAPR for postoperative overall survival (OS) in patients undergoing laparoscopic radical CRC was .495 as shown by univariate and multifactorial Cox regression analysis. The factors of age ≤65 years, Tumor-Node-Metastasis (TNM) stage I-II, tumor grading (high/medium differentiation), CEA ≤5, and AAPR ≥.495 were associated with better OS (P < .05).Preoperative AAPR level was a good predictor of postoperative survival in patients undergoing laparoscopic radical CRC surgery, and AAPR <.495 was an independent risk factor for decreased postoperative OS.