肿瘤相关癫痫（TRE）是脑肿瘤的常见和重要后果。在整个疾病过程中，需要对TRE进行管理，而对诊断和治疗的深入了解是改善生活质量的关键。从肿瘤学和癫痫学的角度来看，全切除手术是首选。肿瘤生长和癫痫存在共同机制，新出现的数据将提供更好的靶向治疗选择。通常情况下，通过抗癫痫药物（ASM）的初始治疗结合手术和/或化疗放疗是常见的治疗方案。考虑到肿瘤本身的影响，ASM的首选药物对于优化癫痫控制和耐受性至关重要。这些药物可能存在药物相互作用的潜力，因此需要了解其作用机制和相互作用。评估不良反应是指导ASM调整和决策的必要依据。本综述重点介绍了TRE的诊断和治疗的关键方面，包括ASM、手术、化疗和放疗，并指出了存在不确定性的领域。未来的研究应考虑使用标准化的癫痫追踪方法，并将癫痫结果作为肿瘤治疗试验的主要终点。© 作者（们） 2023。由牛津大学出版社代表神经肿瘤学会出版。版权所有。有关权限，请发送电子邮件至：journals.permissions@oup.com。

Tumor-related epilepsy (TRE) is a frequent and major consequence of brain tumors. Management of TRE is required throughout the course of disease and a deep understanding of diagnosis and treatment is key to improving quality of life. Gross total resection is favored from both an oncologic and epilepsy perspective. Shared mechanisms of tumor growth and epilepsy exist, and emerging data will provide better targeted therapy options. Initial treatment with antiseizure medications (ASM) in conjunction with surgery and/or chemoradiotherapy is typical. The first choice of ASM is critical to optimize seizure control and tolerability considering the effects of the tumor itself. These agents carry a potential for drug-drug interactions and therefore knowledge of mechanisms of action and interactions is needed. A review of adverse effects is necessary to guide ASM adjustments and decision-making. This review highlights the essential aspects of diagnosis and treatment of TRE with ASMs, surgery, chemotherapy, and radiotherapy while indicating areas of uncertainty. Future studies should consider the use of a standardized method of seizure tracking and incorporating seizure outcomes as a primary endpoint of tumor treatment trials.© The Author(s) 2023. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.