三氧化二砷（ATO）是一项在急性早幼粒细胞白血病（APL）治疗中取得的重大发现，被广泛用于恶性疾病的治疗。系统化的综合分析将有助于准确理解ATO的机制并发现新的联合用药。因此，我们通过手工编制了一个全面的ATO数据库，命名为ATOdb，收集了来自3479篇文章的大量实验证据支持的ATO相关数据，并集成了分析工具。当前版本的ATOdb包含了2300个ATO靶点、80个条件和262种联合药物之间的8373个关联。ATOdb的每个条目都包含了有关ATO靶点、治疗/副作用、系统、细胞名称、细胞类型、调控、检测方法、简要描述、参考文献等详细信息。此外，ATOdb还提供了数据可视化和分析结果，例如药物相似性、蛋白质相互作用和miRNA-mRNA关系。ATOdb的网页界面易于使用，用户可以轻松浏览、搜索和下载数据。总之，ATOdb将作为深入研究ATO机制、发现新的药物联合策略、促进合理用药和个体化治疗的宝贵资源。ATOdb可免费访问网址：http://bio-bigdata.hrbmu.edu.cn/ATOdb/index.jsp。版权所有 © 2023 Elsevier Ltd. 保留所有权利。

Arsenic trioxide (ATO) is a great discovery in the treatment of acute promyelocytic leukemia (APL), which has been used in an increasing number of malignant diseases. Systematic integrative analysis will help to precisely understand the mechanism of ATO and find new combined drugs. Therefore, we developed a one-stop comprehensive database of ATO named ATOdb by manually compiling a wealth of experimentally supported ATO-related data from 3479 articles, and integrated analysis tools. The current version of ATOdb contains 8373 associations among 2300 ATO targets, 80 conditions and 262 combined drugs. Each entry in ATOdb contains detailed information on ATO targets, therapeutic/side effects, systems, cell names, cell types, regulations, detection methods, brief descriptions, references, etc. Furthermore, ATOdb also provides data visualization and analysis results such as the drug similarities, protein-protein interactions, and miRNA-mRNA relationships. An easy-to-use web interface was deployed in ATOdb for users to easily browse, search and download the data. In conclusion, ATOdb will serve as a valuable resource for in-depth study of the mechanism of ATO, discovery of new drug combination strategies, promotion of rational drug use and individualized treatments. ATOdb is freely available at http://bio-bigdata.hrbmu.edu.cn/ATOdb/index.jsp.Copyright © 2023 Elsevier Ltd. All rights reserved.