本研究提出了一种新颖的方法，利用氨基功能化的高质量多壁碳纳米管（MWCNT-NH2）构建了一种敏感且选择性良好的电化学传感器，用于检测塔拉索帕尼（TLZ）在真实样品中的含量，塔拉索帕尼是一种poly (ADP-ribose)聚合酶（PARP）抑制剂。基于MWCNT-NH2的传感器展现了卓越的性能特征，包括良好的重复性、可再生性和高选择性，能够对各种干扰物进行有效区分。在优化条件下，传感器呈现了宽广的线性浓度范围（1.0-5.0 μM），低检测限（LOD）达到0.201 μM。通过对药物和生物基质进行严格的分析，验证了我们的方法的可靠性，回收率达到了96.38-105.25%的令人满意的范围。MWCNT-NH2基传感器在实际样品分析中的成功应用凸显了其在临床和制药领域的潜力。本研究不仅推动了MWCNT-NH2在电化学传感领域的应用，也为创新抗癌治疗的开发和监测开辟了新途径。从我们的研究中获得的见解具有深远的意义，指向了未来精确和创新相结合以改善患者护理和治疗结果的方向。版权所有 © 2023 Elsevier Inc. 发行

In this research, we propose a novel approach for constructing a sensitive and selective electrochemical sensor utilizing high-quality multi-walled carbon nanotubes functionalized with amino groups (MWCNT-NH2) for the detection of Talazoparib (TLZ), a poly (ADP-ribose) polymerase (PARP) enzyme inhibitor, in real samples. The MWCNT-NH2-based sensor exhibited remarkable performance characteristics, including excellent repeatability, reproducibility, and high selectivity against various interferences. Under optimized conditions, the sensor demonstrated a wide linear concentration range of 1.0-5.0 μM, with a low limit of detection (LOD) of 0.201 μM. Substantiated by rigorous analysis of pharmaceutical and biological matrices, our methodology emerges as a paragon of reliability, boasting recovery rates within the satisfactory bracket of 96.38-105.25%. The successful application of the MWCNT-NH2-based sensor in practical sample analysis highlights its potential for implementation in clinical and pharmaceutical settings. This research not only advances the application of MWCNT-NH2 in electrochemical sensing but also opens new avenues for the development and monitoring of innovative anticancer treatments. The insights gained from our study have far-reaching implications, pointing toward a future where precision and innovation converge to improve patient care and treatment outcomes.Copyright © 2023. Published by Elsevier Inc.