研究动态
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高脂饮食诱导的非酒精性脂肪性肝病中的自噬功能障碍。

Dysfunction of autophagy in high-fat diet-induced nonalcoholic fatty liver disease.

发表日期:2023 Sep 12
作者: Qiannan Ren, Qiming Sun, Junfen Fu
来源: Autophagy

摘要:

ACOX1:酰基辅酶A氧化酶1;ADH5:酒精脱氢酶5(III类),χ多肽;ADIPOQ:脂联素,C1Q和胶原结构域蛋白;ATG:自噬相关;BECN1:beclin 1;CRTC2:CREB调节转录激活物2;ER:内质网;F2RL1:F2R类胰凝乳酶受体1;FA:脂肪酸;FOXO1:Forkhead盒O1;GLP1R:胰高血糖素样肽1受体;GRK2:G蛋白偶联受体激酶2;GTPase:鸟苷三磷酸酶;HFD:高脂饮食;HSCs:肝星状细胞;HTRA2:HtrA丝氨酸蛋白酶2;IRGM:免疫相关GTP酶M;KD:沉默;KDM6B:赖氨酸去甲基化酶6B;KO:敲除;LAMP2:溶酶体相关膜蛋白2;LAP:LC3相关吞噬作用;LDs:脂滴;Li KO:肝特异性敲除;LSECs:肝窦内皮细胞;MAP1LC3/LC3:微管相关蛋白1轻链3;MAP3K5:有丝分裂活化蛋白激酶激酶激酶5;MED1:介导体复合物亚单位1;MTOR:雷帕霉素酸酶机械靶蛋白激酶;MTORC1:雷帕霉素酸酶蛋白激酶复合物1;NAFLD:非酒精性脂肪肝病;NASH:非酒精性脂肪性肝炎;NFE2L2:NFE2样bZIP转录因子2;NOS3:一氧化氮合酶3;NR1H3:核受体亚家族1群H成员3;OA:油酸;OE:过量表达;OSBPL8:类固醇与氧化的结合蛋白8;PA:棕榈酸;RUBCNL:与自噬增强相关的抑制剂;PLIN2:固醇密度脂蛋白2;PLIN3:固醇密度脂蛋白3;PPARA:过氧化物酶体增殖激活受体α;PRKAA2/AMPK:蛋白激酶D激活催化亚基α2;RAB:RAS家族肿瘤基因成员;RPTOR:雷帕霉素酸酶复合物1相关蛋白;SCD:硬脂酰辅酶A脱饱和酶;SIRT1:Sir2般1;SIRT3:Sir2般3;SNARE:可溶性N-乙酰硫酰亚胺敏感因子连接蛋白受体;SQSTM1/p62:包裹体1;SREBF1:甾醇调节元件结构域结合转录因子1;SREBF2:甾醇调节元件结构域结合转录因子2;STING1:干扰素应答cGAMP相互作用物1激活剂;STX17:syntaxin 17;TAGs:三酸甘油酯;TFEB:转录因子EB;TP53/p53:肿瘤蛋白p53;ULK1:未51类自噬活化激酶1;VMP1:液泡膜蛋白1。
ACOX1: acyl-CoA oxidase 1; ADH5: alcohol dehydrogenase 5 (class III), chi polypeptide; ADIPOQ: adiponectin, C1Q and collagen domain containing; ATG: autophagy related; BECN1: beclin 1; CRTC2: CREB regulated transcription coactivator 2; ER: endoplasmic reticulum; F2RL1: F2R like trypsin receptor 1; FA: fatty acid; FOXO1: forkhead box O1; GLP1R: glucagon like peptide 1 receptor; GRK2: G protein-coupled receptor kinase 2; GTPase: guanosine triphosphatase; HFD: high-fat diet; HSCs: hepatic stellate cells; HTRA2: HtrA serine peptidase 2; IRGM: immunity related GTPase M; KD: knockdown; KDM6B: lysine demethylase 6B; KO: knockout; LAMP2: lysosomal associated membrane protein 2; LAP: LC3-associated phagocytosis; LDs: lipid droplets; Li KO: liver-specific knockout; LSECs: liver sinusoidal endothelial cells; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MAP3K5: mitogen-activated protein kinase kinase kinase 5; MED1: mediator complex subunit 1; MTOR: mechanistic target of rapamycin kinase; MTORC1: mechanistic target of rapamycin complex 1; NAFLD: non-alcoholic fatty liver disease; NASH: non-alcoholic steatohepatitis; NFE2L2: NFE2 like bZIP transcription factor 2; NOS3: nitric oxide synthase 3; NR1H3: nuclear receptor subfamily 1 group H member 3; OA: oleic acid; OE: overexpression; OSBPL8: oxysterol binding protein like 8; PA: palmitic acid; RUBCNL: rubicon like autophagy enhancer; PLIN2: perilipin 2; PLIN3: perilipin 3; PPARA: peroxisome proliferator activated receptor alpha; PRKAA2/AMPK: protein kinase AMP-activated catalytic subunit alpha 2; RAB: member RAS oncogene family; RPTOR: regulatory associated protein of MTOR complex 1; SCD: stearoyl-CoA desaturase; SIRT1: sirtuin 1; SIRT3: sirtuin 3; SNARE: soluble N-ethylmaleimide-sensitive factor attachment protein receptor; SQSTM1/p62: sequestosome 1; SREBF1: sterol regulatory element binding transcription factor 1;SREBF2: sterol regulatory element binding transcription factor 2; STING1: stimulator of interferon response cGAMP interactor 1; STX17: syntaxin 17; TAGs: triacylglycerols; TFEB: transcription factor EB; TP53/p53: tumor protein p53; ULK1: unc-51 like autophagy activating kinase 1; VMP1: vacuole membrane protein 1.