在结肠直肠癌（CRC）模型中，谷物中的多酚已经展示了一些保护机制；然而，在人体研究中尚缺乏确认。因此，本研究考察了墨尔本合作队列研究（MCCS）中谷物多酚摄入与CRC风险之间的关联。该澳大利亚墨尔本的前瞻性队列研究于1990年至1994年期间招募了参与者以探究饮食与疾病的关系。通过与多酚数据匹配的食物频率问卷饮食数据，估算了从谷物中摄入的烷基间苯酚、酚酸、木脂素和总多酚的饮食摄入量。使用多元调整的Cox比例风险模型，以最低摄入五分位数作为对照类别，估算了结肠直肠癌风险的风险比（HR）和95%置信区间，根据年龄作为时间轴，调整了性别、社会经济地位、饮酒量、纤维摄入量、出生国家、总能量摄入量、身体活动和吸烟状况。从35,245名合格成年人中（平均（SD）年龄54.7（8.6）岁，大部分为女性（61%）和澳大利亚出生（69%）），共有1394例CRC（946例结肠癌和448例直肠癌）发病。总谷物多酚摄入的结果显示Q2（HR：0.80；95% CI，0.68-0.95）和Q4（HR：0.75；95% CI，0.62-0.90）的HR降低，酚酸的情况类似。烷基间苯酚摄入显示Q3（HR：0.80；95% CI，0.67-0.95）和Q4（HR：0.79；95% CI，0.66-0.95）的HR降低。总体而言，本研究显示谷物多酚摄入与CRC风险之间关联证据有限。未来的研究可能有助于了解谷物来源多酚与不同人群中的其他癌症之间的关联。 © 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

Cereal-derived polyphenols have demonstrated protective mechanisms in colorectal cancer (CRC) models; however, confirmation in human studies is lacking. Therefore, this study examined the association between cereal polyphenol intakes and CRC risk in the Melbourne Collaborative Cohort Study (MCCS), a prospective cohort study in Melbourne, Australia that recruited participants between 1990 and 1994 to investigate diet-disease relationships.Using food frequency questionnaire diet data matched to polyphenol data, dietary intakes of alkylresorcinols, phenolic acids, lignans, and total polyphenols from cereals were estimated. Hazard ratios (HRs) and 95% confidence intervals for CRC risk were estimated for quintiles of intake with the lowest quintile as the comparison category, using multivariable adjusted Cox proportional hazards models with age as the time axis adjusted for sex, socio-economic status, alcohol consumption, fibre intake, country of birth, total energy intake, physical activity and smoking status.From 35,245 eligible adults, mean (SD) age 54.7 (8.6) years, mostly female (61%) and Australian-born (69%), there were 1394 incident cases of CRC (946 colon cancers and 448 rectal cancers). Results for total cereal polyphenol intake showed reduced HRs in Q2 (HR: 0.80; 95% CI, 0.68-0.95) and Q4 (HR: 0.75; 95% CI, 0.62-0.90), and similar for phenolic acids. Alkylresorcinol intake showed reduced HR in Q3 (HR: 0.80; 95% CI, 0.67-0.95) and Q4 (HR: 0.79; 95% CI, 0.66-0.95).Overall, the present study showed little evidence of association between intakes of cereal polyphenols and CRC risk. Future investigations may be useful to understand associations between cereal-derived polyphenols and additional cancers in different populations.© 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.