阿尔茨海默病（AD）是最常见的痴呆症类型，是一种进行性认知功能障碍的神经退行性疾病。流行病学调查表明，在心血管和脑血管疾病、肿瘤和其他原因之后，AD已成为影响老年人的重大健康问题，其死亡率每年急剧增加。调节性细胞死亡是基因决定的细胞主动、有序死亡，是生物体发育中无处不在的，对生命稳态调节至关重要。通过对AD中调节性细胞死亡的广泛研究，越来越多的证据表明，铁死、火死和铜死与AD的发生、发展和预后密切相关。本文将综述铁死、火死和铜死的分子机制及其在AD中的调节作用，以探索AD治疗的潜在治疗靶点。

Alzheimer's disease (AD), the most common type of dementia, is a neurodegenerative disorder characterized by progressive cognitive dysfunction. Epidemiological investigation has demonstrated that, after cardiovascular and cerebrovascular diseases, tumors, and other causes, AD has become a major health issue affecting elderly individuals, with its mortality rate acutely increasing each year. Regulatory cell death is the active and orderly death of genetically determined cells, which is ubiquitous in the development of living organisms and is crucial to the regulation of life homeostasis. With extensive research on regulatory cell death in AD, increasing evidence has revealed that ferroptosis, pyroptosis, and cuproptosis are closely related to the occurrence, development, and prognosis of AD. This paper will review the molecular mechanisms of ferroptosis, pyroptosis, and cuproptosis and their regulatory roles in AD to explore potential therapeutic targets for the treatment of AD.