磷酸果糖激酶（PFK）是参与糖酵解的关键酶之一。研究表明，PFKP通过糖酵解和糖酵解无关的功能调节细胞增殖、凋亡、自噬、细胞迁移/转移和干细胞特性。PFKP不仅在细胞质中发挥功能，还分布在细胞膜、线粒体、溶酶体膜和细胞核中。在癌细胞中广泛研究了PFKP的功能。PFKP在某些免疫细胞中也高表达，然而，对PFKP在免疫细胞中的作用的研究还有限。在本综述中，我们总结了PFKP在癌细胞中的表达和活性是如何调控的。由于在癌细胞中过度表达以及重要功能，PFKP可能成为一种预后标志物。因此，针对/抑制PFKP可能是癌症治疗的关键和有希望的策略。版权所有 © 2023. 由Elsevier Inc.发表。

Phosphofructokinase (PFK) is one of the key enzymes that functions in glycolysis. Studies show that PFKP regulates cell proliferation, apoptosis, autophagy, cell migration/metastasis, and stemness through glycolysis and glycolysis-independent functions. PFKP performs its function not only in the cytoplasm, but also at the cell membrane, on the mitochondria, at the lysosomal membrane, and in the nucleus. The functions of PFKP are extensively studied in cancer cells. PFKP is also highly expressed in certain immune cells; nevertheless, the study of the PFKP's role in immune cells is limited. In this review, we summarize how the expression and activity of PFKP are regulated in cancer cells. PFKP may be applied as a prognostic marker due to its overexpression and significant functions in cancer cells. As such, specifically targeting/inhibiting PFKP may be a critical and promising strategy for cancer therapy.Copyright © 2023. Published by Elsevier Inc.