细胞应激是癌症固有的，也是肿瘤发生的关键推动因素。最近的研究表明，细胞应激通过非膜内器官——应激颗粒体（stress granules, SGs）促进肿瘤发生。尽管关于SGs的生物学是一个新兴的领域，但至今的所有研究都指出，与正常细胞相比，癌细胞形成SGs的能力增强，癌细胞更加依赖SGs在不良环境下的生存和化疗耐药性，肿瘤依赖SGs促进生长。为什么癌细胞对SGs依赖，并且SGs如何促进肿瘤发生仍有待阐明。在这里，我们试图通过将SGs定位为肿瘤相关应激刺激的一种激素反应，为回答这些问题提供一个框架。版权所有 © 2023 Elsevier Inc. 保留所有权利。

Cell stress is inherent to cancer and a key driver of tumorigenesis. Recent studies have proposed that cell stress promotes tumorigenesis through non-membranous organelles known as stress granules (SGs). While the biology of SGs is an emerging field, all studies to date point to the enhanced ability of cancer cells to form SGs compared with normal cells, a heightened dependence on SGs for survival under adverse conditions and for chemotherapy resistance, and the dependence of tumors on SGs for growth. Why cancer cells become dependent on SGs and how SGs promote tumorigenesis remain to be elucidated. Here, we attempt to provide a framework for answering these questions by framing SGs as a hormetic response to tumor-associated stress stimuli.Copyright © 2023 Elsevier Inc. All rights reserved.