明胞肾细胞癌（CCRCC）是泌尿系统常见的肿瘤，手术是首选治疗方法，但手术后缺乏治疗选择。本研究旨在从遗传学角度探讨GNG7在CCRCC中的生物学作用。利用TCGA数据库分析CCRCC患者和健康患者中GNG7的mRNA表达差异和患者存活情况。观察到与健康组织相比，CCRCC组织中GNG7基因表达下调，高GNG7预示患者预后较好，且GNG7在临床和TMN分期中也表现出较高的变异性。利用CCLE和TISIDB数据库分析了GNG7及相关基因的免疫相关性。验证了由7个与GNG7相关的调节因子构建的风险评分可能作为CCRCC的独立预后风险因子。进一步建立了涉及7个免疫基因的CCRCC预后模型，以预测患者的生存概率。最后，利用GEO数据库和免疫组织化学染色验证了CCRCC中GNG7的表达。我们的研究提出了一个基于GNG7相关免疫基因的CCRCC OS预测基因组，可以帮助准确预测CCRCC患者的预后，并为个体化治疗作出更好的临床决策。© 2023. BioMed Central Ltd., part of Springer Nature.

Clear cell renal cell carcinoma (CCRCC) is a common tumor of the urological system for which surgery is the preferred treatment, but there is a lack of therapeutic options after surgery. This study aims to explore the biological role of GNG7 on CCRCC from a genetic perspective. Differences in mRNA expression and patient survival of GNG7 in patients with CCRCC and healthy patients were analyzed using the TCGA database. It was observed that GNG7 gene expression was downregulated in CCRCC tissue compared with healthy tissue, and high GNG7 predicted better prognosis for patients, and GNG7 also showed strong variability in clinical and TMN staging. The immune relevance of GNG7 and related genes was explored using renal cancer data from CCLE and TISIDB database. It was verified that the risk score constructed by 7 GNG7-related regulators might be used as an independent prognostic risk factor for CCRCC. A CCRCC prognostic model that involved 7 immune genes was further established to predict the survival probabilities of patients. At last, the GEO database and immunochemical tissue staining were used to validate GNG7 expression in CCRCC. Our study proposed a novel panel of genes to predict CCRCC OS based on GNG7-related immune genes, which may help to accurately predict the prognosis of CCRCC patients and make better clinical decisions for individual treatment.© 2023. BioMed Central Ltd., part of Springer Nature.