基于金的纳米颗粒具有出色的光学性能，推动了它们在生物医学领域的广泛应用，从生物成像到光热应用。然而，常用的金基纳米颗粒制备方法需要长时间和繁琐的操作流程，降低了成本效益和可扩展性。在本文中，我们采用了一种新颖的方法来生产具有光热性能的金-海藻酸纳米杂化体（Au-Alg-NH）。通过使用抗坏血酸促进金离子在海藻酸基质中的原位还原和成核，实现了这一目标。所得结果显示，Au-Alg-NH具有均匀的尺寸分布和针状形态。此外，纳米材料能够在近红外区域（NIR）激光（808 nm，1.7 W cm-2）照射下导致温度升高约11°C。体外实验证明，Au-Alg-NH能够以NIR光诱导的方式消融癌细胞（MCF-7），细胞存活率下降约27%。因此，结果表明，这种新颖的制备方法具有生产具有光热能力且更易转化为临床实践的Au-Alg-NH的潜力，尤其在癌症治疗方面。

Gold-based nanoparticles present excellent optical properties that propelled their widespread application in biomedicine, from bioimaging to photothermal applications. Nevertheless, commonly employed manufacturing methods for gold-based nanoparticles require long periods and laborious protocols that reduce cost-effectiveness and scalability. Herein, a novel methodology was used for producing gold-alginic acid nanohybrids (Au-Alg-NH) with photothermal capabilities. This was accomplished by promoting the in situ reduction and nucleation of gold ions throughout a matrix of alginic acid by using ascorbic acid. The results obtained reveal that the Au-Alg-NHs present a uniform size distribution and a spike-like shape. Moreover, the nanomaterials were capable to mediate a temperature increase of ≈11°C in response to the irradiation with a near-infrared region (NIR) laser (808 nm,1.7 W cm-2 ). The in vitro assays showed that Au-Alg-NHs were able to perform a NIR light-triggered ablation of cancer cells (MCF-7), being observed a reduction in the cell viability to ≈27%. Therefore, the results demonstrate that this novel methodology holds the potential for producing Au-Alg-NH with photothermal capacity and higher translatability to the clinical practice, namely for cancer therapy. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.