[标题] 生物钟对癌症发病和进展的核心成分及功能 [正文] 昼夜节律是由分子生物钟自主振荡器所发展起来的，它在24小时的日常周期中，协调内部时间与外部环境的关键作用。在哺乳动物中，这个生物钟系统在所有的生理过程中都起着重要的作用，对人类健康产生了深远影响。生物钟的调节不仅限于时钟基因，还涉及到多个由时钟调控的基因。因此，这些时钟基因的表达异常会导致控制细胞周期和凋亡能力的重要靶标的下调，可能导致基因组的不稳定性并促进癌症发生。时钟基因的改变和调控已被认为是开发有效治疗多种疾病的新方法，包括癌症。至今对于生物钟和癌症的关系还存在着理解的不足。因此，本章旨在阐明生物钟的核心成分及其在癌症发病和进展中的功能。此外，还讨论了临床影响、现有的时钟药物以及潜在的治疗靶点。 [版权声明] 版权归© 2023 Elsevier Inc.所有。

Circadian rhythms are autonomous oscillators developed by the molecular circadian clock, essential for coordinating internal time with the external environment in a 24-h daily cycle. In mammals, this circadian clock system plays a major role in all physiological processes and severely affects human health. The regulation of the circadian clock extends beyond the clock genes to involve several clock-controlled genes. Hence, the aberrant expression of these clock genes leads to the downregulation of important targets that control the cell cycle and the ability to undergo apoptosis. This may lead to genomic instability and promotes carcinogenesis. Alteration in the clock genes and their modulation is recognized as a new approach for the development of effective treatment against several diseases, including cancer. Until now, there has been a lack of understanding of circadian rhythms and cancer disease. For that, this chapter aims to represent the core components of circadian rhythms and their function in cancer pathogenesis and progression. In addition, the clinical impacts, current clock drugs, and potential therapeutic targets have been discussed.Copyright © 2023. Published by Elsevier Inc.