量子生物跨膜电子转移参与了控制生命的基本功能，如细胞呼吸和体内稳态。理解和控制生物中的量子效应有潜力调节生物功能。在这里，我们将无线纳米电化学工具与癌细胞结合，以控制电子转移来触发癌细胞凋亡。通过功能化红氧鸟呈星和氧化还原介质锌卟啉的金双极性纳米电极，我们开发了作为电场刺激生物驱动器的生物纳米天线。我们展示了远程电输入调节这些氧化还原分子之间的电子传输，从而导致量子生物跨膜电子转移以选择性地触发患者源性癌细胞的凋亡。转录组学数据显示，电场诱导的生物纳米天线以独特方式靶向癌细胞，代表了电气诱导的分子信号控制。该研究展示了量子基于的医学诊断和治疗的潜力。© 2023年。作者。

Quantum biological tunnelling for electron transfer is involved in controlling essential functions for life such as cellular respiration and homoeostasis. Understanding and controlling the quantum effects in biology has the potential to modulate biological functions. Here we merge wireless nano-electrochemical tools with cancer cells for control over electron transfer to trigger cancer cell death. Gold bipolar nanoelectrodes functionalized with redox-active cytochrome c and a redox mediator zinc porphyrin are developed as electric-field-stimulating bio-actuators, termed bio-nanoantennae. We show that a remote electrical input regulates electron transport between these redox molecules, which results in quantum biological tunnelling for electron transfer to trigger apoptosis in patient-derived cancer cells in a selective manner. Transcriptomics data show that the electric-field-induced bio-nanoantenna targets the cancer cells in a unique manner, representing electrically induced control of molecular signalling. The work shows the potential of quantum-based medical diagnostics and treatments.© 2023. The Author(s).