侵蚀性食管炎（EE）是胃食管反流病（GERD）谱系的一部分，可能发展为食管腺癌。由于其进展性和不明确的患病率，我们的目标是确定对EE有贡献的因素，以决定是否需要进一步检查。我们通过PubMed和其他资源进行了基于PRISMA 2020的系统搜索，截至2022年6月2日。使用纽卡斯尔-渥塔华评分（NOS）评估研究质量。测量了每个因素的比值比（OR）和世界范围内的EE患病率。共纳入了114项观察性研究，共759,100名参与者。在29个因素中，重要的风险因素包括年龄≥60岁（OR 2.03 [1.81-2.28]）、白人/高加索人（OR 1.67 [1.40-1.99]）、未婚（OR 1.08 [1.03-1.14]）、GERD持续≥5年（OR 1.27 [1.14-1.42]）、全身肥胖（OR 1.78 [1.61-1.98]）、腹部肥胖（OR 1.29 [1.18-1.42]）、糖尿病（OR 1.24 [1.17-1.32]）、高血压（OR 1.16 [1.09-1.23]）、血脂异常（OR 1.15 [1.06-1.24]）、高三酰甘油血症（OR 1.42 [1.29-1.57]）、裂孔疝（OR 4.07 [3.21-5.17]）和非酒精性脂肪肝病（NAFLD）（OR 1.26 [1.18-1.34]）。然而，幽门螺杆菌感染（OR 0.56 [0.48-0.66]）和萎缩性胃炎（OR 0.51 [0.31-0.86]）对EE具有保护作用。该研究表明，年龄、种族、未婚、长期GERD、代谢性疾病、裂孔疝和NAFLD是EE的风险因素，而幽门螺杆菌感染和萎缩性胃炎是其保护因素。这些发现有助于更好地理解EE，并增强对其日益加重的负担的认识。© 2023 Springer Nature 有限公司。

Erosive esophagitis (EE) is the part of gastroesophageal reflux disease (GERD) spectrum and may progress to esophageal adenocarcinoma. Due to its progressivity and unclear prevalence, we aim to identify the factors contributing in EE to decide the need for further examination. We performed a PRISMA 2020-based systematic search through PubMed and other resources up to June 2, 2022. Study quality was assessed using the Newcastle-Ottawa Scale (NOS). The odds ratio (OR) of each factor and worldwide prevalence of EE were measured. There are 114 observational studies included with a total of 759,100 participants. Out of 29 factors, the significant risk factors are age ≥ 60 y.o. (OR 2.03 [1.81-2.28]), White/Caucasian (OR 1.67 [1.40-1.99]), unmarried (OR 1.08 [1.03-1.14]), having GERD ≥ 5 years (OR 1.27 [1.14-1.42]), general obesity (OR 1.78 [1.61-1.98]), central obesity (OR 1.29 [1.18-1.42]), diabetes mellitus (DM) (OR 1.24 [1.17-1.32]), hypertension (OR 1.16 [1.09-1.23]), dyslipidemia (OR 1.15 [1.06-1.24]), hypertriglyceridemia (OR 1.42 [1.29-1.57]), hiatal hernia (HH) (OR 4.07 [3.21-5.17]), and non-alcoholic fatty liver disease (NAFLD) (OR 1.26 [1.18-1.34]). However, H. pylori infection (OR 0.56 [0.48-0.66]) and atrophic gastritis (OR 0.51 [0.31-0.86]) are protective towards EE. This study demonstrates that age, ethnicity, unmarried, long-term GERD, metabolic diseases, HH, and NAFLD act as risk factors for EE, whereas H. pylori infection and atrophic gastritis act as protective factors. These findings may enable a better understanding of EE and increase greater awareness to address its growing burden.© 2023. Springer Nature Limited.