本综述旨在强调用于控制危险药物管理步骤的计算机程序的重要性。必须考虑到，在药房服务中处理危险药物的过程中存在着对处理这些药物的医疗人员构成风险的阶段。目标：通过回顾科学文献，确定在医院药房管理危险药物（HDs）方面已经使用过哪些计算机程序。从成立到2021年7月30日，通过以下电子数据库进行搜索：MEDLINE（通过PubMed）、Embase、Cochrane图书馆、Scopus、Web of Science、拉丁美洲和加勒比地区医学文献（LILACS）和西班牙医学（MEDES）。在搜索策略中使用了以下术语：“抗肿瘤药物”、“细胞毒性药物”、“危险物质”、“医学信息学应用”、“移动应用程序”、“软件”、“软件设计”和“医院药房服务”。从数据库中检索到了104项研究，并通过手工检索所包含研究的参考文献和请教专家等方式获取到了另外18项研究。一旦应用了纳入和排除标准，最终纳入该综述的研究共有26项。在纳入研究中描述的大多数应用程序用于抗肿瘤药物的管理。电子处方是最常控制的阶段；18项研究和7项干预措施集中评估了化疗制剂准确性的问题。抗肿瘤药物电子处方软件是在医院层面上应用最广泛的软件。没有发现控制整个HD过程的软件。只有一项选定的研究对处理HD的工人的安全事件进行了测量。此外，发现医护人员对这类技术在日常工作中与这些药物合作方面的实施感到满意。所审查的所有研究均将患者安全视为最终目标。然而，没有一项研究评估了工人接触HD的风险。 版权所有 © 2023 Climent-Ballester、García-Salom和Sanz-Valero。

This review wants to highlight the importance of computer programs used to control the steps in the management of dangerous drugs. It must be taken into account that there are phases in the process of handling dangerous medicines in pharmacy services that pose a risk to the healthcare personnel who handle them. Objective: To review the scientific literature to determine what computer programs have been used in the field of hospital pharmacy for the management of dangerous drugs (HDs).The following electronic databases were searched from inception to July 30, 2021: MEDLINE (via PubMed), Embase, Cochrane Library, Scopus, Web of Science, Latin American and Caribbean Literature in Health Sciences (LILACS) and Medicine in Spanish (MEDES). The following terms were used in the search strategy: "Antineoplastic Agents," "Cytostatic Agents," "Hazardous Substances," "Medical Informatics Applications," "Mobile Applications," "Software," "Software Design," and "Pharmacy Service, Hospital."A total of 104 studies were retrieved form the databases, and 18 additional studies were obtained by manually searching the reference lists of the included studies and by consulting experts. Once the inclusion and exclusion criteria were applied, 26 studies were ultimately included in this review. Most of the applications described in the included studies were used for the management of antineoplastic drugs. The most commonly controlled stage was electronic prescription; 18 studies and 7 interventions carried out in the preparation stage focused on evaluating the accuracy of chemotherapy preparations.Antineoplastic electronic prescription software was the most widely implemented software at the hospital level. No software was found to control the entire HD process. Only one of the selected studies measured safety events in workers who handle HDs. Moreover, health personnel were found to be satisfied with the implementation of this type of technology for daily work with these medications. All studies reviewed herein considered patient safety as their final objective. However, none of the studies evaluated the risk of HD exposure among workers.Copyright © 2023 Climent-Ballester, García-Salom and Sanz-Valero.