肉瘤是罕见的癌症，其位置、组织学亚型和治疗方法非常异质化。鲜有研究探索肉瘤患者的健康相关生命质量（HRQoL）的纵向研究。本研究于2017年9月至2020年2月在德国的39个研究中心对成人肉瘤患者进行了评估和随访，持续一年。随访时间点为入组后的6个月（t1）和12个月（t2）。我们采用了一个标准化、经验证的问卷（欧洲肿瘤研究与治疗组织质量生活核心问卷（EORTC QLQ-C30）），并使用广义线性混合模型探索了两个人群（所有患者（分析1）和处于持续完全缓解状态的患者（分析2））中HRQoL的预测因素。总共纳入了1111名患者作为基线（t1时915名，t2时847名），其中387名参与者在基线时处于完全缓解状态（t1时334名，t2时200名）。分析所有患者时，与肿瘤位置相比，肢体下肢肉瘤患者报告的HRQoL值较低。包括放射治疗和/或全身治疗在内的治疗与较低的HRQoL相关。对于处于完全缓解状态的患者，吸烟与较差的HRQoL结果相关。在两个分析中，骨肉瘤与最差的HRQoL值相关。女性、年龄在55-<65岁之间、较低的社会经济地位和共病状况都与较低的HRQoL有关。HRQoL在治疗后的一段时间内部分上升，并且与运动活动有关。HRQoL随着治疗时间的推移而改善，尽管并非在所有领域，与生活方式和社会经济因素有关。骨肉瘤是受影响最严重的亚群。应制定保护和改善肉瘤患者HRQoL的方法。 版权所有 © 2023 Eichler，Hentschel，Singer，Hornemann，Richter，Hofbauer，Hohenberger，Kasper，Andreou，Pink，Jakob，Grützmann，Fung，Wardelmann，Arndt，Hermes-Moll，Schoffer，Fried，Jambor，Weitz，Schaser，Bornhäuser，Schmitt和Schuler。

Sarcomas are rare cancers and very heterogeneous in their location, histological subtype, and treatment. Health-Related Quality of Life (HRQoL) of sarcoma patients has rarely been investigated in longitudinal studies.Here, we assessed adult sarcoma patients and survivors between September 2017 and February 2020, and followed-up for one year in 39 study centers in Germany. Follow-up time points were 6 (t1) and 12 months (t2) after inclusion. We used a standardized, validated questionnaire (the European Organisation for Research and Treatment of Cancer Quality of Life Core Instrument (EORTC QLQ-C30) and explored predictors of HRQoL in two populations (all patients (Analysis 1), patients in ongoing complete remission (Analysis 2)) using generalized linear mixed models.In total we included up to 1111 patients at baseline (915 at t1, and 847 at t2), thereof 387 participants were in complete remission at baseline (334 at t1, and 200 at t2). When analyzing all patients, HRQoL differed with regard to tumor locations: patients with sarcoma in lower extremities reported lower HRQoL values than patients with sarcomas in the upper extremities. Treatment which included radiotherapy and/or systemic therapy was associated with lower HRQoL. For patients in complete remission, smoking was associated with worse HRQoL-outcomes. In both analyses, bone sarcomas were associated with the worst HRQoL values. Being female, in the age group 55-<65 years, having lower socioeconomic status, and comorbidities were all associated with a lower HRQoL, in both analyses.HRQoL increased partially over time since treatment and with sporting activities. HRQoL improved with time since treatment, although not in all domains, and was associated with lifestyle and socioeconomic factors. Bone sarcomas were the most affected subgroup. Methods to preserve and improve HRQoL should be developed for sarcoma patients.Copyright © 2023 Eichler, Hentschel, Singer, Hornemann, Richter, Hofbauer, Hohenberger, Kasper, Andreou, Pink, Jakob, Grützmann, Fung, Wardelmann, Arndt, Hermes-Moll, Schoffer, Fried, Jambor, Weitz, Schaser, Bornhäuser, Schmitt and Schuler.