多模态癌症治疗在通过不同机制协同增强抗癌效力方面显示出巨大的潜力。然而，大多数当前的多模态治疗要么依赖于多功能纳米材料和药物分子的复杂组合，要么使用具有较差体内降解/代谢能力的纳米医药，从而限制了其临床可转化性。在这里，我们通过一步法水热法合成了一种纳米药物，使用铁离子、硫鸟嘌呤（TG）和四羧基卟啉（TCPP）作为构建块，用于联合化疗/化学动力学/光动力学治疗癌症。所得的纳米花，由低密度Fe2O3内核和铁络合物（Fe-TG和Fe-TCPP化合物）外壳组成，具有高积聚于肿瘤部位、理想的肿瘤微环境中降解能力、强大的抑制肿瘤生长和转移能力，以及有效重拾宿主抗肿瘤免疫力。在肿瘤微环境中的低pH刺激下，纳米花在内吞后逐渐降解，从而实现有效药物释放，并在肿瘤部位精确启动高效催化反应。此外，铁离子在完成任务后可以通过肾脏清除体外。令人惊讶的是，我们还发现，多模态协同治疗有效地引发了宿主抗肿瘤免疫，而不会引起额外的毒性。这种易制备和可降解的多模态治疗纳米医药对临床精准肿瘤学有很大的前景。本文受版权保护。版权所有。

Multimodal cancer therapies show great promise in synergistically enhancing anticancer efficacy through different mechanisms. However, most current multimodal therapies either rely on complex assemblies of multiple functional nanomaterials and drug molecules, or involve the use of nanomedicines with poor in-vivo degradability/metabolizability, thus restricting their clinical translatability. Herein, we have synthesized a nanoflower-medicine using iron ions, thioguanine (TG) and tetracarboxylic porphyrin (TCPP) as building blocks through one-step hydrothermal method for combined chemo/chemodynamic/photodynamic cancer therapy. The resulted nanoflowers, consisting of low-density Fe2 O3 core and iron complex (Fe-TG and Fe-TCPP compounds) shell, exhibited high accumulation at the tumor site, desirable degradability in the TME, robust suppression of tumor growth and metastasis, as well as effective reinvigoration of host antitumor immunity. Triggered by the low pH in tumor microenvironment, the nanoflowers gradually degrade after internalization, contributing to the effective drug release and initiation of high-efficiency catalytic reactions precisely in tumor sites. Moreover, iron ions could be eliminated from the body through renal clearance after fulfilling their mission. Strikingly, we also find that the multimodal synergistic therapy effectively elicits the host antitumor immunity without inducing additional toxicity. This easy-manufactured and degradable multimodal therapeutic nanomedicine is promising for clinical precision oncology. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.