植物多酚在抗癌治疗方面显示出了令人充满希望的应用。越来越多的证据表明，多酚对多种癌症具有抗肿瘤潜力。非编码RNA（ncRNA），主要包括小型ncRNA（microRNA）和长ncRNA（lncRNA），在癌症的发生和发展中起着关键作用。为了确立多酚对ncRNA的调节作为一种新型和有希望的抗癌治疗方法，本研究利用ncRNA、miRNA、lncRNA和调控机制等关键词，从PubMed、Web of Science、Science Direct和Google Scholar检索文献，时间跨度为2003年至2023年的20年。本研究批判性地审查了当前的文献，并呈现了多酚对突出的ncRNA的调控情况。共检索到169篇关于多酚及其相关ncRNA在癌症中的文献。ncRNA，主要包括miRNA和lncRNA，在癌症的发生和发展中起着关键作用，这些ncRNA是生物活性多酚，如白藜芦醇、异黄酮、姜黄素、EGCG、槲皮素在癌症管理中潜在的调控靶点。多酚介导的ncRNA调控的机制包括表观遗传和转录修饰以及转录后加工。调控性的ncRNA是生物活性多酚的潜在治疗靶点，并且这些植物化合物可以直接和间接地改变这些ncRNA的水平。对多酚在癌症中通过ncRNA调控的更好理解，以及其对肿瘤病理生理学和调控分子机制的功能结果，可能有助于制定有效的抗击这一毁灭性疾病的策略。版权所有©2023. Elsevier GmbH出版。

Plant polyphenols have shown promising applications in oncotherapy. Increasing evidence reveals that polyphenols possess the antitumor potential for multiple cancers. Non-coding RNAs (ncRNAs), mainly including small ncRNAs (microRNA) and long ncRNAs (lncRNAs), play critical roles in cancer initiation and progression.To establish the modulation of ncRNAs by polyphenols as a novel and promising approach in anticancer treatment.The present research employed ncRNA, miRNA, lncRNA, and regulatory mechanism as keywords to retrieve the literature from PubMed, Web of Science, Science direct, and Google Scholar, in a 20-year period from 2003 to 2023. This study critically reviewed the current literature and presented the regulation of prominent ncRNAs by polyphenols. A comprehensive total of 169 papers were retrieved on polyphenols and their related ncRNAs in cancers.NcRNAs, mainly including miRNA and lncRNA, play critical roles in cancer initiation and progression, which are potential modulatory targets of bioactive polyphenols, such as resveratrol, genistein, curcumin, EGCG, quercetin, in cancer management. The mechanism involved in polyphenol-mediated ncRNA regulation includes epigenetic and transcriptional modification, and post-transcriptional processing.Regulatory ncRNAs are potential therapeutic targets of bioactive polyphenols, and these phytochemicals could modulate the level of these ncRNAs directly and indirectly. A better comprehension of the ncRNA regulation by polyphenols in cancers, their functional outcomes on tumor pathophysiology and regulatory molecular mechanisms, may be helpful to develop effective strategies to fight the devastating disease.Copyright © 2023. Published by Elsevier GmbH.