鳞状细胞癌心转录本编辑酶催化亚基类3C (A3C) 在人类多种恶性肿瘤中的作用并不一致。A3C 的表达与早期乳腺癌有关，并被视为一种良好的预后因子；然而，在低级别胶质瘤中，它却对细胞毒药物的治疗效果产生了较小的影响。为了探索 A3C 对胶质瘤的影响，我们对多个公共数据库进行了统计分析。结果显示，增强的 A3C 表达与肿瘤分级的提高和预后因子的表达降低相关。同样，我们的体外研究表明，与正常脑组织 cDNA 和裂解物相比，胶质母细胞瘤 (GBM) 细胞系具有更高的 A3C mRNA 和蛋白质表达水平。我们首先进行了免疫组织化学染色 (IHC)，证明了具有高 A3C 表达的胶质瘤呈现出野生型异柠檬酸脱氢酶 1 (IDH1)，并且在人类胶质瘤组织中具有不良的预后。此外，与 A3C 表达相关的肿瘤学因子暗示了 DNA 修复途径是在胶质瘤中诱导肿瘤发生和化疗抗药性的重要机制。此外，我们观察到 A3C 表达与蛋白脂质 2 (PLP2) 之间存在显著相关性。活化的氧化应激 (ROS) 与 PLP2 抑制 DNA 损伤诱导的细胞凋亡。与 A3C 和/或 PLP2 高免疫染色分数相比，A3C 和 PLP2 低免疫染色分数的联合表达与胶质瘤患者生存率的提高相关；然而，具体的机制有待阐明。总之，我们的结果不仅确认了 A3C 在胶质瘤发展中的重要作用，而且 A3C 的免疫组织化学试验能够成功预测治疗效果和疾病预后。

The roles of apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3C (A3C) in various human malignancies are not consistent. A3C expression is correlated with early-stage breast cancer and is presented as a good prognostic factor; however, it induces fewer therapeutic effects of cytotoxic drugs in low-grade gliomas. To explore the impact of A3C on gliomas, a statistical analysis of several public databases was conducted. The results showed that enhanced A3C expression was associated with advanced tumor grades and poor expression of prognostic factors. Similarly, our in vitro study revealed that glioblastoma (GBM) cell lines had higher A3C mRNA and protein expression than that of normal brain tissue cDNA and lysates. We first performed an immunohistochemical stain (IHC) to prove that gliomas with high A3C expression presented the wild type-Isocitrate dehydrogenase 1 (IDH1), and they had an unfavorable prognosis in human glioma tissues. In addition, the oncological factors associated with A3C expression suggested that DNA repair pathways are important mechanisms for inducing tumorigenesis and chemoresistance in gliomas. Moreover, a significant correlation was observed between A3C expression and proteolipid protein 2  (PLP2). Reactive oxygen species (ROS) -activated PLP2 prevents DNA damage-induced cell apoptosis. Compared to high immunostaining scores for A3C and/or PLP2 expression, combined low immunostaining scores for A3C and PLP2 correlated with improved survival in gliomas; however, the detailed mechanism is to be elucidated. In conclusion, our results not only confirmed A3C played an important role in glioma development, but the A3C IHC test could successfully predict the therapeutic effects and disease prognosis.