狗和人类的肿瘤具有许多相似的分子和遗传特征，这有助于更好地了解犬肿瘤，不仅是为了治疗伴侣动物，而且还有助于以免疫学能力强的方式研究具有相似生物学行为和治疗方法的自发肿瘤。动物模型。这两个物种的多种肿瘤类型都通过磷脂酰肌醇 3 激酶 (PI3K)、蛋白激酶 B (PKB；AKT) 和雷帕霉素靶点 (mTOR) 发生类似的信号转导失调，统称为 PI3K-AKT-mTOR 通路。本综述旨在描述 PI3K-AKT-mTOR 信号通路在健康和肿瘤发展中的相关方面。然后，它将概述目前对重要犬类癌症中 PI3K-AKT-mTOR 信号传导的了解以及该通路靶向抑制剂的进展。

Tumors in dogs and humans share many similar molecular and genetic features, incentivizing a better understanding of canine neoplasms not only for the purpose of treating companion animals, but also to facilitate research of spontaneously developing tumors with similar biologic behavior and treatment approaches in an immunologically competent animal model. Multiple tumor types of both species have similar dysregulation of signal transduction through phosphatidylinositol 3-kinase (PI3K), protein kinase B (PKB; AKT), and mechanistic target of rapamycin (mTOR), collectively known as the PI3K-AKT-mTOR pathway. This review aims to delineate the pertinent aspects of the PI3K-AKT-mTOR signaling pathway in health and in tumor development. It will then present a synopsis of current understanding of PI3K-AKT-mTOR signaling in important canine cancers and advancements in targeted inhibitors of this pathway.