最先进的联合放化疗和图像引导近距离放射治疗治疗局部晚期宫颈癌（LACC）已显示出改善的疾病控制和生存率以及器官相关发病率的显着降低。然而，LACC 癌症幸存者仍然出现一系列症状。本研究的目的是通过使用患者报告的结果和医生评估的发病率来识别宫颈癌幸存者的并发症状。EMBRACE I 是一项针对 1416 名 LACC 患者的多中心前瞻性观察研究（2008-2015 年）。分别使用 CTCAE v.3 和 EORTC-C30/CX24 在基线和定期随访中评估医生评估的发病率和患者报告的结果的信息。纳入至少随访 2 年的患者，并使用 3 个月至 2 年的数据进行分析。对 EORTC 和 CTCAE 数据进行因子分析，并以症状和随访作为观察结果。提取的因素代表症状群。随后，建立回归模型来研究症状群与生活质量之间的关联。分析包括 742 名患者。尽管医生评估的症状和患者报告的症状的定义存在差异，但这两种评估方法发现了类似的症状。泌尿、胃肠道和阴道发病可分为三个主要的器官相关群。此外，还发现疲劳、疼痛、失眠、神经病、潮热等较重的一般症状。最后，还发现了一组伴有恶心、呕吐和食欲不振的症状。一般症状、胃肠道和恶心症状群与一般生活质量显着相关。对 PRO 和医生评估的发病率的分析发现，症状群与一般症状和器官相关症状群（泌尿、胃肠道、阴道）相关。这表明 LACC 幸存者会经历多种同时出现的症状。我们的分析还表明，一系列一般症状与生活质量下降有关。

State of the art combined radiochemotherapy and image-guided brachytherapy for locally advanced cervical cancer (LACC) has shown improved disease control and survival as well as a significant reduction of organ related morbidity. However, LACC cancer survivors are still experiencing a spectrum of symptoms. The aim of this study was to identify co-occurring symptoms in cervix cancer survivors by using patient-reported outcome and physician assessed morbidity.EMBRACE I is a multicenter prospective observational study with 1416 LACC patients (2008-2015). Information on physician-assessed morbidity and patient-reported outcome was assessed at baseline and at regular follow-ups up with the CTCAE v.3 and EORTC-C30/CX24, respectively. Patients with at least 2 years of follow-up were included and data from 3 months to 2 years was used in the analysis. Factor analysis was used on both EORTC and CTCAE data with symptoms and follow-ups as observations. The extracted factors represent clusters of symptoms. Subsequently, regression models were built to investigate associations between the symptom clusters and QOL.The analysis included 742 patients. Despite the differences in the definition of physician-assessed and patient-reported symptoms, similar clusters are identified by the two assessment methods. Three main organ-related clusters are recognized for urinary, gastro-intestinal and vaginal morbidity. Furthermore, a general symptoms cluster where fatigue, pain, insomnia, neuropathy, and hot flashes have large weights is found. Lastly, a cluster with nausea, vomit and lack of appetite is also identified. The general, gastrointestinal and nausea clusters show significant associations with general QOL.This analysis on both PRO and physician-assessed morbidity found a cluster associated with general symptoms and organ-related symptom clusters (urinary, gastrointestinal, vaginal). This shows that LACC survivors experience a variety of co-occurring symptoms. Our analysis also shows that the cluster of general symptoms is associated with a decrease in QOL.