声动力疗法（SDT）是在光动力疗法（PDT）基础上提出的一种新型非侵入性治疗方法。具有精度高、组织穿透力强、副作用小、患者依从性好等优点。随着纳米医学的成熟，纳米声敏剂的应用进一步推动了SDT的发展。近年来，人们开发了许多新型声敏剂并探索了SDT的作用机制。其中，关于自噬与SDT关系的研究日益受到关注。 SDT后，细胞通常会发生自噬作为一种自我保护机制，以抵抗外界刺激并减少细胞损伤，这有利于动脉粥样硬化（AS）、糖尿病和心肌梗塞的治疗，但在癌症治疗中却适得其反。然而，在某些治疗条件下，自噬的过度上调也可以促进细胞死亡，这有利于癌症治疗。本文综述了SDT与自噬在癌症、AS、糖尿病、心肌梗死等疾病中关系的最新研究进展。我们还讨论并提出了通过调节自噬来增强 SDT 疗效的挑战和前景，希望能够促进这种有前景的治疗方法的发展。版权所有 © 2023。由 Elsevier Inc. 出版。

Sonodynamic therapy (SDT) is a new non-invasive treatment method proposed based on photodynamic therapy (PDT). It has advantages such as high precision, strong tissue penetration, minimal side effects, and good patient compliance. With the maturation of nanomedicine, the application of nanosonosensitizers has further propelled the development of SDT. In recent years, people have developed many new types of sonosensitizers and explored the mechanisms of SDT. Among them, the studies about the relationship between autophagy and SDT have attracted increasing attention. After the SDT, cells usually undergo autophagy as a self-protective mechanism to resist external stimuli and reduce cell damage, which is beneficial for the treatment of atherosclerosis (AS), diabetes, and myocardial infarction but counterproductive in cancer treatment. However, under certain treatment conditions, excessive upregulation of autophagy can also promote cell death, which is beneficial for cancer treatment. This article reviews the latest research progress on the relationship between SDT and autophagy in cancers, AS, diabetes, and myocardial infarction. We also discuss and propose the challenges and prospects in enhancing SDT efficacy by regulating autophagy, with the hope of promoting the development of this promising therapeutic approach.Copyright © 2023. Published by Elsevier Inc.