主动监测 (AS) 是大多数低风险前列腺癌 (PC) 男性的标准护理；然而，许多患有 AS 的男性最终还是接受了治疗。需要采取干预措施来降低患有 PC 的 AS 男性的癌症进展风险和对复发的恐惧。为了确定有氧运动对患有 PC 的 AS 的男性心肺健康、体型和生活质量 (QOL) 的影响。我们在 51 名选择 AS 的低风险 PC 男性中进行了 1:1 随机对照试验。参与者是加州大学旧金山分校的参与者。为期 16 周的干预措施包括家庭步行计划、根据基线健身水平量身定制的非线性运动处方、心率监测器以及每周与运动生理学家通话。对照组接受印刷材料。使用 VO2peak 测量心肺健康；次要结果包括体型、焦虑和生活质量的变化。分析基于治疗意向。2016 年至 2021 年间，我们将 51 名男性随机分为干预组 (n = 26) 或对照组 (n = 25)。干预组的随访率为 88% (45/51)、85% (22/26)，对照组为 92% (23/25)。第 16 周时，干预组的平均 VO2peak 高于对照组（31.9 ± 4.7 vs 27.2 ± 4.8 ml/kg/min；组 × 时间效应 p 值：<0.001）。此外，干预组报告称对 PC 复发和尿路梗阻/刺激的恐惧较少，而对照组则报告了更多的这两项 QOL 指标，从 0 周到 16 周（分别为 p = 0.04 和 0.03）。两名参与者停止了干预，其中一名是因为与研究相关的膝盖疼痛。家庭步行计划改善了 VO2peak，减少了接受 PC 治疗的 AS 男性的尿路梗阻/刺激和对复发的恐惧。中等到剧烈的有氧运动可以改善体能和健康状况。积极监测前列腺癌的男性生活质量。版权所有 © 2023 作者。由 Elsevier B.V. 出版。保留所有权利。

Active surveillance (AS) is standard care for most men with low-risk prostate cancer (PC); yet, many men on AS eventually undergo curative therapy. Interventions to lower the risk of cancer progression and fear of recurrence among men on AS for PC are needed.To determine the effect of aerobic exercise on cardiorespiratory fitness, body size, and quality of life (QOL) among men on AS for PC.We conducted a 1:1 randomized controlled trial among 51 men with low-risk PC who elected AS. Participants were enrolled at the University of California, San Francisco.The 16-wk intervention included a home-based walking program with a nonlinear exercise prescription tailored to baseline fitness level, heart rate monitor, and weekly phone call with an exercise physiologist. Controls received printed materials.Cardiorespiratory fitness was measured using VO2peak; secondary outcomes included change in body size, anxiety, and QOL. Analyses were based on intention to treat.Between 2016 and 2021, we randomized 51 men to intervention (n = 26) or control (n = 25). Follow-up was 88% (45/51), 85% (22/26) in the intervention and 92% (23/25) in the control group. At 16 wk, the intervention group had a higher mean VO2peak than the control group (31.9 ± 4.7 vs 27.2 ± 4.8 ml/kg/min; group × time effect p value: <0.001). Additionally, the intervention group reported less fear of PC recurrence and urinary obstruction/irritation, while controls reported more of these two QOL measures, from 0 to 16 wk (p = 0.04 and 0.03, respectively). Two participants discontinued the intervention, including one due to knee pain related to the study.A home-based walking program improved VO2peak and reduced urinary obstruction/irritation and fear of recurrence among men on AS for PC.Moderate to vigorous aerobic exercise improves fitness and quality of life among men on active surveillance for prostate cancer.Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.