最近，模拟禁食饮食和热量限制已被证明可以提高抗肿瘤免疫力。在本期《癌症研究》中，钟和同事深入探讨了结直肠癌进展中模拟禁食饮食介导的代谢重编程的分子机制。作者在小鼠模型中进行了全面的机制实验，结果表明，模拟禁食饮食可以通过加速脂肪酸氧化来抑制 B 细胞 IgA 类别转换，从而降低瘤内 IgA B 细胞，从而预防结直肠癌进展。此外，他们发现脂肪酸氧化依赖性乙酰化可防止 IgA 类别转换，并且 IgA B 细胞会干扰模拟禁食饮食对结直肠癌的抗癌作用。总体而言，他们的研究表明，模拟禁食饮食有可能激活抗癌免疫力并诱导结直肠癌的肿瘤消退。参见Zhong等人的相关文章，第17页。 3529.©2023 美国癌症研究协会。

Recently, fasting-mimicking diet and caloric restriction have been shown to improve antitumor immunity. In this issue of Cancer Research, Zhong and colleagues provide insights into the molecular mechanism of fasting-mimicking diet-mediated metabolic reprogramming in colorectal cancer progression. The authors performed comprehensive mechanistic experiments in mouse models to show that fasting-mimicking diet prevents colorectal cancer progression by lowering intratumoral IgA+ B cells by accelerating fatty acid oxidation to inhibit B-cell IgA class switching. In addition, they found that fatty acid oxidation-dependent acetylation prevents IgA class switching and that IgA+ B cells interfere with the anticancer effects of fasting-mimicking diet in colorectal cancer. Overall, their study establishes that fasting-mimicking diet has the potential to activate anticancer immunity and to induce tumor regression in colorectal cancer. See related article by Zhong et al., p. 3529.©2023 American Association for Cancer Research.