评估接受微创手术 (MIS) 治疗的明显早期子宫内膜癌 (EC) 的复发率和模式，并将其与接受剖腹手术治疗的“历史”人群进行比较。次要结局是确定在 MIS 复发患者中，中高风险/高风险患者与低/中风险患者相比是否表现出相同的复发模式，并评估研究人群的首次复发时间 (TTR)。 多中心回顾性观察研究。五个意大利妇科肿瘤转诊中心。2017 年 1 月至 2022 年 6 月期间，所有经 MIS 治疗的明显早期 EC 复发的患者。剖腹手术历史队列来自《腹腔镜检查与剖腹手术对子宫癌综合手术分期的比较：妇科肿瘤组研究 (LAP2)》和《腹腔镜子宫内膜癌治疗方法》试验。评估复发率和模式。77 例复发在中位随访时间为 36 个月期间，共有 1028 名患者接受 MIS 治疗，明显处于早期 EC 阶段。我们队列中的复发率与历史队列中的复发率没有显着差异（7.4% vs 7.9%，比值比 0.9395，95% CI 0.6901-1.2792）。局部、腹部、淋巴结和多部位复发模式没有发现显着差异；历史队列患者中远处复发的可能性更大。与中高/高风险患者相比，术后低/中风险患者局部复发的可能性更高。平均 TTR 为 19 个月。与其他复发模式相比，未观察到每种复发模式的 TTR 存在显着差异。MIS 对于治疗早期 EC 似乎是安全的。我们没有发现任何与早期 EC 中的 MIS 特别相关的复发模式。版权所有 © 2024 AAGL。由爱思唯尔公司出版。保留所有权利。

To evaluate recurrence rate and pattern in apparently early-stage endometrial cancer (EC) treated with minimally invasive surgery (MIS) and compare it to the "historical" populations treated by laparotomy. Secondary outcomes were to establish if, among MIS recurrent patients, intermediate-high/high-risk patients presented the same recurrence pattern compared to those at low/intermediate-risk and to evaluate time to first recurrence (TTR) of the study population.Multicenter retrospective observational study.Five Italian Gynecologic Oncology referral centers.All patients with proven recurrence of apparently early-stage EC treated with MIS from January 2017 to June 2022 . The laparotomic historical cohort was obtained from Laparoscopy Compared With Laparotomy for Comprehensive Surgical Staging of Uterine Cancer: Gynecologic Oncology Group Study (LAP2) and Laparoscopic Approach to Cancer of the Endometrium trials.Evaluation of recurrence rate and pattern.Seventy-seven recurrences occurred on the total of 1028 patients treated with MIS for apparently early-stage EC during a median follow-up time of 36 months. The rate of recurrence in our cohort did not differ significantly from the rate of the historical cohort (7.4% vs 7.9%, odds ratio 0.9395, 95% CI 0.6901-1.2792). No significant differences were noticed for local, abdominal, nodal, and multiple site recurrence patterns; distant site recurrence appeared more likely in patients from the historical cohort. Postoperative low/intermediate risk patients had a higher likelihood of local recurrence compared to intermediate-high/high risk patients. Mean TTR was 19 months. No significant difference of TTR was observed for each pattern of recurrence compared to others.MIS appears to be safe for the treatment of early-stage EC. We did not identify any recurrence pattern specifically associated with MIS in early-stage EC.Copyright © 2024 AAGL. Published by Elsevier Inc. All rights reserved.